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@ARTICLE{Muschallik:885450,
      author       = {Muschallik, Lukas and Kipp, Carina Ronja and Recker, Inga
                      and Bongaerts, Johannes and Pohl, Martina and Gellissen,
                      Melanie and Schöning, Michael J. and Selmer, Thorsten and
                      Siegert, Petra},
      title        = {{S}ynthesis of α-hydroxy ketones and vicinal diols with
                      the {B}acillus licheniformis {DSM} 13{T} butane-2,3-diol
                      dehydrogenase},
      journal      = {Journal of biotechnology},
      volume       = {324},
      issn         = {0168-1656},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2020-03833},
      pages        = {61 - 70},
      year         = {2020},
      abstract     = {The enantioselective synthesis of α-hydroxy ketones and
                      vicinal diols is an intriguing field because of the broad
                      applicability of these molecules. Although, butandiol
                      dehydrogenases are known to play a key role in the
                      production of 2,3-butandiol, their potential as biocatalysts
                      is still not well studied. Here, we investigate the
                      biocatalytic properties of the meso-butanediol dehydrogenase
                      from Bacillus licheniformis DSM 13T (BlBDH). The encoding
                      gene was cloned with an N-terminal StrepII-tag and
                      recombinantly overexpressed in E. coli. BlBDH is highly
                      active towards several non-physiological diketones and
                      α-hydroxyketones with varying aliphatic chain lengths or
                      even containing phenyl moieties. By adjusting the reaction
                      parameters in biotransformations the formation of either the
                      α-hydroxyketone intermediate or the diol can be
                      controlled.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {581 - Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32976868},
      UT           = {WOS:000600955400007},
      doi          = {10.1016/j.jbiotec.2020.09.016},
      url          = {https://juser.fz-juelich.de/record/885450},
}