Home > Publications database > Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2,3-diol dehydrogenase > print

001     885450
005     20210130010410.0
024 7 _ |a 10.1016/j.jbiotec.2020.09.016
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024 7 _ |a 0168-1656
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024 7 _ |a 1873-4863
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024 7 _ |a 2128/26006
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100 1 _ |a Muschallik, Lukas
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245 _ _ |a Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2,3-diol dehydrogenase
260 _ _ |a Amsterdam [u.a.]
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520 _ _ |a The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.
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700 1 _ |a Kipp, Carina Ronja
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700 1 _ |a Recker, Inga
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700 1 _ |a Bongaerts, Johannes
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700 1 _ |a Pohl, Martina
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700 1 _ |a Gellissen, Melanie
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700 1 _ |a Schöning, Michael J.
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700 1 _ |a Selmer, Thorsten
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700 1 _ |a Siegert, Petra
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773 _ _ |a 10.1016/j.jbiotec.2020.09.016
|g Vol. 324, p. 61 - 70
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|t Journal of biotechnology
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856 4 _ |y Published on 2020-09-22. Available in OpenAccess from 2021-09-22.
|u https://juser.fz-juelich.de/record/885450/files/Muschallik%20et%20all%20JBIOTEC-S-20-01483.pdf
856 4 _ |y Published on 2020-09-22. Available in OpenAccess from 2021-09-22.
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