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@ARTICLE{Hogenkamp:885458,
author = {Hogenkamp, Fabian and Hilgers, Fabienne and Knapp, Andreas
and Klaus, Oliver and Bier, Claus and Binder, Dennis and
Jaeger, Karl-Erich and Drepper, Thomas and Pietruszka,
Jörg},
title = {{E}ffect of {P}hotocaged {I}sopropyl
β‐d‐1‐{T}hiogalactopyranoside {S}olubility on
{L}ight‐{R}esponsiveness of {L}ac{I}‐controlled
{E}xpression {S}ystems in {D}ifferent {B}acteria},
journal = {ChemBioChem},
volume = {22},
number = {3},
issn = {1439-7633},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {FZJ-2020-03841},
pages = {539-547},
year = {2021},
abstract = {Photolabile protecting groups play a significant role in
controlling biological functions and cellular processes in
living cells and tissues, as light offers high
spatiotemporal control, is non‐invasive as well as easily
tuneable. In the recent past, photo‐responsive inducer
molecules such as 6‐nitropiperonyl‐caged IPTG
(NP‐cIPTG) have been used as optochemical tools for Lac
repressor‐controlled microbial expression systems. To
further expand the applicability of the versatile
optochemical on‐switch, we have investigated whether the
modulation of cIPTG water solubility can improve the light
responsiveness of appropriate expression systems in
bacteria. To this end, we developed two new cIPTG
derivatives with different hydrophobicity and demonstrated
both an easy applicability for the light‐mediated control
of gene expression and a simple transferability of this
optochemical toolbox to the biotechnologically relevant
bacteria Pseudomonas putida and Bacillus subtilis. Notably,
the more water‐soluble cIPTG derivative proved to be
particularly suitable for light‐mediated gene expression
in these alternative expression hosts.},
cin = {IBOC / IBG-1 / IMET},
ddc = {540},
cid = {I:(DE-Juel1)IBOC-20090406 / I:(DE-Juel1)IBG-1-20101118 /
I:(DE-Juel1)IMET-20090612},
pnm = {2171 - Biological and environmental resources for
sustainable use (POF4-217)},
pid = {G:(DE-HGF)POF4-2171},
typ = {PUB:(DE-HGF)16},
pubmed = {32914927},
UT = {WOS:000581110400001},
doi = {10.1002/cbic.202000377},
url = {https://juser.fz-juelich.de/record/885458},
}