TY  - JOUR
AU  - Altenburg, Bianca
AU  - Frings, Marcus
AU  - Schöbel, Jan-Hendrik
AU  - Goßen, Jonas
AU  - Pannen, Kristina
AU  - Vanderliek, Kim
AU  - Rossetti, Giulia
AU  - Koschmieder, Steffen
AU  - Chatain, Nicolas
AU  - Bolm, Carsten
TI  - Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies
JO  - ACS medicinal chemistry letters
VL  - 11
IS  - 10
SN  - 1948-5875
CY  - Washington, DC
PB  - ACS
M1  - FZJ-2020-03848
SP  - 1928–1934
PY  - 2020
AB  - Structural analogues of PFI-1 varying at the sulfur core were prepared, and their activities as BET inhibitors in myeloid cell lines and primary cells from patients with acute myeloid leukemia were studied. Docking calculations followed by molecular dynamics simulations revealed the binding mode of the newly prepared inhibitors, suggesting explanations for the observed high enantiospecificity of the inhibitory activity.
LB  - PUB:(DE-HGF)16
C6  - 33062175
UR  - <Go to ISI:>//WOS:000580567800022
DO  - DOI:10.1021/acsmedchemlett.9b00625
UR  - https://juser.fz-juelich.de/record/885465
ER  -