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@ARTICLE{Eickhoff:885559,
      author       = {Eickhoff, Roman Marius and Kroh, Andreas and Eickhoff,
                      Simon and Heise, Daniel and Helmedag, Marius Julian and
                      Tolba, Rene H and Klinge, Uwe and Neumann, Ulf Peter and
                      Klink, Christian Daniel and Lambertz, Andreas},
      title        = {{A} peritoneal defect covered by intraperitoneal mesh
                      prosthesis effects an increased and distinctive foreign body
                      reaction in a minipig model},
      journal      = {Journal of biomaterials applications},
      volume       = {35},
      number       = {6},
      issn         = {1530-8022},
      address      = {Thousand Oaks, Calif. [u.a.]},
      publisher    = {Sage},
      reportid     = {FZJ-2020-03930},
      pages        = {732-739},
      year         = {2020},
      note         = {The author(s) disclosed receipt of the following financial
                      supportfor the research, authorship, and/or publication of
                      thisarticle: This study was granted by the BMBF
                      (FederalMinistry of Education and Research) (Funding
                      number:13N12599.},
      abstract     = {Background: The incidence of incisional hernia is with up
                      to $30\%$ one of the frequent long-term complication
                      afterlaparotomy. After establishing minimal invasive
                      operations, the laparoscopic intraperitoneal onlay mesh
                      technique(lap. IPOM) was first described in 1993. Little is
                      known about the foreign body reaction of IPOM-meshes, which
                      covereda defect of the parietal peritoneum. This is becoming
                      more important, since IPOM procedure with
                      peritoneal-sacresection and hernia port closing (IPOM plus)
                      is more frequently used.Methods: In 18 female minipigs, two
                      out of three Polyvinylidene-fluoride (PVDF) -meshes (I:
                      standard IPOM; II: IPOMwith modified structure [bigger
                      pores]; III: IPOM with the same structure as IPOM
                      IIþdegradable hydrogel-coating)were placed in a
                      laparoscopic IPOM procedure. Before mesh placement, a 2x2cm
                      peritoneal defect was created. After30 days, animals were
                      euthanized, adhesions were evaluated by re-laparoscopy and
                      mesh samples were explanted forhistological and
                      immunohistochemichal investigations.Results: All animals
                      recovered after implantation and had no complications during
                      the follow-up period. Analysingforeign body reaction, the
                      IPOM II mesh had a significant smaller inner granuloma,
                      compared to the other meshes (IPOMII: 8.4 mm1.3 vs. IPOM I
                      9.1 mm1.3, p<0.001). The degradable hydrogel coating does
                      not prevent adhesionsmeasured by Diamond score (p¼0.46). A
                      peritoneal defect covered by a standard or modified IPOM
                      mesh was asignificant factor for increasing foreign body
                      granuloma, the amount of CD3þ lymphocytes, CD68þ
                      macrophages anddecrease of pore size.Conclusion: A
                      peritoneal defect covered by IPOM prostheses leads to an
                      increased foreign body reaction compared tointact
                      peritoneum. Whenever feasible, a peritoneal defect should be
                      closed accurately before placing an IPOM-mesh toavoid an
                      excessive foreign body reaction and therefore inferior
                      biomaterial properties of the prosthesis.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33331198},
      UT           = {WOS:000583370400001},
      doi          = {10.1177/0885328220963918},
      url          = {https://juser.fz-juelich.de/record/885559},
}