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| 001 | 885559 | ||
| 005 | 20210104120139.0 | ||
| 024 | 7 | _ | |a 10.1177/0885328220963918 |2 doi |
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| 024 | 7 | _ | |a 1530-8022 |2 ISSN |
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| 100 | 1 | _ | |a Eickhoff, Roman Marius |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a A peritoneal defect covered by intraperitoneal mesh prosthesis effects an increased and distinctive foreign body reaction in a minipig model |
| 260 | _ | _ | |a Thousand Oaks, Calif. [u.a.] |c 2020 |b Sage |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a The author(s) disclosed receipt of the following financial supportfor the research, authorship, and/or publication of thisarticle: This study was granted by the BMBF (FederalMinistry of Education and Research) (Funding number:13N12599. |
| 520 | _ | _ | |a Background: The incidence of incisional hernia is with up to 30% one of the frequent long-term complication afterlaparotomy. After establishing minimal invasive operations, the laparoscopic intraperitoneal onlay mesh technique(lap. IPOM) was first described in 1993. Little is known about the foreign body reaction of IPOM-meshes, which covereda defect of the parietal peritoneum. This is becoming more important, since IPOM procedure with peritoneal-sacresection and hernia port closing (IPOM plus) is more frequently used.Methods: In 18 female minipigs, two out of three Polyvinylidene-fluoride (PVDF) -meshes (I: standard IPOM; II: IPOMwith modified structure [bigger pores]; III: IPOM with the same structure as IPOM IIþdegradable hydrogel-coating)were placed in a laparoscopic IPOM procedure. Before mesh placement, a 2x2cm peritoneal defect was created. After30 days, animals were euthanized, adhesions were evaluated by re-laparoscopy and mesh samples were explanted forhistological and immunohistochemichal investigations.Results: All animals recovered after implantation and had no complications during the follow-up period. Analysingforeign body reaction, the IPOM II mesh had a significant smaller inner granuloma, compared to the other meshes (IPOMII: 8.4 mm1.3 vs. IPOM I 9.1 mm1.3, p<0.001). The degradable hydrogel coating does not prevent adhesionsmeasured by Diamond score (p¼0.46). A peritoneal defect covered by a standard or modified IPOM mesh was asignificant factor for increasing foreign body granuloma, the amount of CD3þ lymphocytes, CD68þ macrophages anddecrease of pore size.Conclusion: A peritoneal defect covered by IPOM prostheses leads to an increased foreign body reaction compared tointact peritoneum. Whenever feasible, a peritoneal defect should be closed accurately before placing an IPOM-mesh toavoid an excessive foreign body reaction and therefore inferior biomaterial properties of the prosthesis. |
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| 700 | 1 | _ | |a Heise, Daniel |0 0000-0001-6923-0849 |b 3 |
| 700 | 1 | _ | |a Helmedag, Marius Julian |0 0000-0002-8914-7978 |b 4 |
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| 700 | 1 | _ | |a Neumann, Ulf Peter |b 7 |
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| 700 | 1 | _ | |a Lambertz, Andreas |0 P:(DE-HGF)0 |b 9 |
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