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@ARTICLE{Porcu:885574,
      author       = {Porcu, Emanuele and Benz, Karsta M. and Ball, Felix and
                      Tempelmann, Claus and Hanke, Michael and Noesselt, Toemme},
      title        = {{M}acroscopic information-based taste representations in
                      insular cortex are shaped by stimulus concentration},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {117},
      number       = {13},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2020-03938},
      pages        = {7409 - 7417},
      year         = {2020},
      abstract     = {Taste processing is an essential ability in all animals
                      signaling potential harm or benefit of ingestive behavior.
                      However, current evidence for cortical taste representations
                      remains contradictory. To address this issue,
                      high-resolution functional MRI (fMRI) and multivariate
                      pattern analysis were used to characterize taste-related
                      informational content in human insular cortex, which
                      contains primary gustatory cortex. Human participants judged
                      pleasantness and intensity of low- and high-concentration
                      tastes (salty, sweet, sour, and bitter) in two fMRI
                      experiments on two different days to test for task- and
                      concentration-invariant taste representations. We observed
                      patterns of fMRI activity within insular cortex narrowly
                      tuned to specific tastants consistently across tasks in all
                      participants. Fewer patterns responded to more than one
                      taste category. Importantly, changes in taste concentration
                      altered the spatial layout of putative taste-specific
                      patterns with distinct, almost nonoverlapping patterns for
                      each taste category at different concentration levels.
                      Together, our results point at macroscopic representations
                      in human insular cortex as a complex function of taste
                      category and concentration rather than representations based
                      solely on taste identity.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32179687},
      UT           = {WOS:000523188100063},
      doi          = {10.1073/pnas.1916329117},
      url          = {https://juser.fz-juelich.de/record/885574},
}