TY  - JOUR
AU  - Takemura, Hiromasa
AU  - Palomero-Gallagher, Nicola
AU  - Axer, Markus
AU  - Grässel, David
AU  - Jorgensen, Matthew J
AU  - Woods, Roger
AU  - Zilles, Karl
TI  - Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
JO  - eLife
VL  - 9
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - FZJ-2020-04015
SP  - e55444
PY  - 2020
AB  - Although the primate visual system has been extensively studied, detailed spatial organization of white matter fiber tracts carrying visual information between areas has not been fully established. This is mainly due to the large gap between tracer studies and diffusion-weighted MRI studies, which focus on specific axonal connections and macroscale organization of fiber tracts, respectively. Here we used 3D polarization light imaging (3D-PLI), which enables direct visualization of fiber tracts at micrometer resolution, to identify and visualize fiber tracts of the visual system, such as stratum sagittale, inferior longitudinal fascicle, vertical occipital fascicle, tapetum and dorsal occipital bundle in vervet monkey brains. Moreover, 3D-PLI data provide detailed information on cortical projections of these tracts, distinction between neighboring tracts, and novel short-range pathways. This work provides essential information for interpretation of functional and diffusion-weighted MRI data, as well as revision of wiring diagrams based upon observations in the vervet visual system.
LB  - PUB:(DE-HGF)16
C6  - pmid:32844747
UR  - <Go to ISI:>//WOS:000577130900001
DO  - DOI:10.7554/eLife.55444
UR  - https://juser.fz-juelich.de/record/885688
ER  -