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@ARTICLE{Graf:885729,
      author       = {Graf, Michaela and Haas, Thorsten and Teleki, Attila and
                      Feith, André and Cerff, Martin and Wiechert, Wolfgang and
                      Nöh, Katharina and Busche, Tobias and Kalinowski, Jörn and
                      Takors, Ralf},
      title        = {{R}evisiting the growth modulon of {C}orynebacterium
                      glutamicum under glucose limited chemostat conditions},
      journal      = {Frontiers in Bioengineering and Biotechnology},
      volume       = {8},
      issn         = {2296-4185},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {FZJ-2020-04041},
      pages        = {584614},
      year         = {2020},
      abstract     = {Increasing the growth rate of the industrial host
                      Corynebacterium glutamicum is a promising target to rise
                      productivities of growth coupled product formation. As a
                      prerequisite, detailed knowledge about the tight regulation
                      network is necessary for identifying promising metabolic
                      engineering goals. Here, we present comprehensive metabolic
                      and transcriptional analysis of C. glutamicum ATCC 13032
                      growing under glucose limited chemostat conditions with μ =
                      0.2, 0.3, and 0.4 h–1. Intermediates of central metabolism
                      mostly showed rising pool sizes with increasing growth.
                      13C-metabolic flux analysis (13C-MFA) underlined the
                      fundamental role of central metabolism for the supply of
                      precursors, redox, and energy equivalents. Global,
                      growth-associated, concerted transcriptional patterns were
                      not detected giving rise to the conclusion that glycolysis,
                      pentose-phosphate pathway, and citric acid cycle are
                      predominately metabolically controlled under
                      glucose-limiting chemostat conditions. However, evidence is
                      found that transcriptional regulation takes control over
                      glycolysis once glucose-rich growth conditions are
                      installed.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {581 - Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33178676},
      UT           = {WOS:000584724900001},
      doi          = {10.3389/fbioe.2020.584614},
      url          = {https://juser.fz-juelich.de/record/885729},
}