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@ARTICLE{Dorst:885797,
      author       = {Dorst, Andrea and Berg, Regina and Gertzen, Christoph G. W.
                      and Schäfle, Daniel and Zerbe, Katja and Gwerder, Myriam
                      and Schnell, Simon D. and Sander, Peter and Gohlke, Holger
                      and Gademann, Karl},
      title        = {{S}emisynthetic {A}nalogs of the {A}ntibiotic
                      {F}idaxomicin—{D}esign, {S}ynthesis, and {B}iological
                      {E}valuation},
      journal      = {ACS medicinal chemistry letters},
      volume       = {11},
      number       = {12},
      issn         = {1948-5875},
      address      = {Washington, DC},
      publisher    = {ACS},
      reportid     = {FZJ-2020-04094},
      pages        = {2414–2420},
      year         = {2020},
      abstract     = {The glycoslated macrocyclic antibiotic fidaxomicin (1,
                      tiacumicin B, lipiarmycin A3) displays good to excellent
                      activity against Gram-positive bacteria and was approved for
                      the treatment of Clostridium difficile infections (CDI).
                      Among the main limitations for this compound, its low water
                      solubility impacts further clinical uses. We report on the
                      synthesis of new fidaxomicin derivatives based on structural
                      design and utilizing an operationally simple one-step
                      protecting group-free preparative approach from the natural
                      product. An increase in solubility of up to 25-fold with
                      largely retained activity was observed. Furthermore, hybrid
                      antibiotics were prepared that show improved antibiotic
                      activities.},
      cin          = {JSC / NIC / IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)IBI-7-20200312},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / Forschergruppe Gohlke $(hkf7_20200501)$},
      pid          = {G:(DE-HGF)POF3-511 / $G:(DE-Juel1)hkf7_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33329763},
      UT           = {WOS:000599586900006},
      doi          = {10.1021/acsmedchemlett.0c00381},
      url          = {https://juser.fz-juelich.de/record/885797},
}