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@ARTICLE{Dukart:885824,
      author       = {Dukart, Juergen and Holiga, Stefan and Rullmann, Michael
                      and Lanzenberger, Rupert and Hawkins, Peter C. T. and Mehta,
                      Mitul A. and Hesse, Swen and Barthel, Henryk and Sabri,
                      Osama and Jech, Robert and Eickhoff, Simon B.},
      title        = {{J}u{S}pace : {A} tool for spatial correlation analyses of
                      magnetic resonance imaging data with nuclear imaging derived
                      neurotransmitter maps},
      journal      = {Human brain mapping},
      volume       = {42},
      number       = {3},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2020-04115},
      pages        = {555-566},
      year         = {2021},
      abstract     = {Recent studies have shown that drug‐induced spatial
                      alteration patterns in resting state functional activity as
                      measured using magnetic resonance imaging (rsfMRI) are
                      associated with the distribution of specific receptor
                      systems targeted by respective compounds. Based on this
                      approach, we introduce a toolbox (JuSpace) allowing for
                      cross‐modal correlation of MRI‐based measures with
                      nuclear imaging derived estimates covering various
                      neurotransmitter systems including dopaminergic,
                      serotonergic, noradrenergic, and GABAergic
                      (gamma‐aminobutric acid) neurotransmission. We apply
                      JuSpace to two datasets covering Parkinson's disease
                      patients (PD) and risperidone‐induced changes in rsfMRI
                      and cerebral blood flow (CBF). Consistently with the
                      predominant neurodegeneration of dopaminergic and
                      serotonergic system in PD, we find significant spatial
                      associations between rsfMRI activity alterations in PD and
                      dopaminergic (D2) and serotonergic systems (5‐HT1b).
                      Risperidone induced CBF alterations were correlated with its
                      main targets in serotonergic and dopaminergic systems.
                      JuSpace provides a biologically meaningful framework for
                      linking neuroimaging to underlying neurotransmitter
                      information.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33079453},
      UT           = {WOS:000579518700001},
      doi          = {10.1002/hbm.25244},
      url          = {https://juser.fz-juelich.de/record/885824},
}