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000885838 1001_ $$0P:(DE-HGF)0$$aDafsari, Haidar S.$$b0$$eCorresponding author
000885838 245__ $$aBeneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson’s disease
000885838 260__ $$aNew York, NY [u.a.]$$bElsevier$$c2020
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000885838 520__ $$aBackgroundSubthalamic (STN) and pallidal (GPi) deep brain stimulation (DBS) improve quality of life, motor, and nonmotor symptoms (NMS) in advanced Parkinson’s disease (PD). However, few studies have compared their nonmotor effects.ObjectiveTo compare nonmotor effects of STN-DBS and GPi-DBS.MethodsIn this prospective, observational, multicenter study including 60 PD patients undergoing bilateral STN-DBS (n = 40) or GPi-DBS (n = 20), we examined PDQuestionnaire (PDQ), NMSScale (NMSS), Unified PD Rating Scale-activities of daily living, -motor impairment, -complications (UPDRS-II, –III, -IV), Hoehn&Yahr, Schwab&England Scale, and levodopa-equivalent daily dose (LEDD) preoperatively and at 6-month follow-up. Intra-group changes at follow-up were analyzed with Wilcoxon signed-rank or paired t-test, if parametric tests were applicable, and corrected for multiple comparisons. Inter-group differences were explored with Mann-Whitney-U/unpaired t-tests. Analyses were performed before and after propensity score matching which balanced out demographic and preoperative clinical characteristics. Strength of clinical changes was assessed with effect size.ResultsIn both groups, PDQ, UPDRS-II, -IV, Schwab&England Scale, and NMSS improved significantly at follow-up. STN-DBS was significantly better for LEDD reduction, GPi-DBS for UPDRS-IV. While NMSS total score outcomes were similar, explorative NMSS domain analyses revealed distinct profiles: Both targets improved sleep/fatigue and mood/cognition, but only STN-DBS the miscellaneous (pain/olfaction) and attention/memory and only GPi-DBS cardiovascular and sexual function domains.
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000885838 7001_ $$0P:(DE-HGF)0$$ados Santos Ghilardi, Maria Gabriela$$b1
000885838 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b2
000885838 7001_ $$0P:(DE-HGF)0$$aRizos, Alexandra$$b3
000885838 7001_ $$0P:(DE-HGF)0$$aAshkan, Keyoumars$$b4
000885838 7001_ $$0P:(DE-HGF)0$$aSilverdale, Monty$$b5
000885838 7001_ $$0P:(DE-HGF)0$$aEvans, Julian$$b6
000885838 7001_ $$0P:(DE-HGF)0$$aMartinez, Raquel C. R.$$b7
000885838 7001_ $$0P:(DE-HGF)0$$aCury, Rubens G.$$b8
000885838 7001_ $$0P:(DE-HGF)0$$aJost, Stefanie T.$$b9
000885838 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b10
000885838 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b11$$ufzj
000885838 7001_ $$0P:(DE-HGF)0$$aAntonini, Angelo$$b12
000885838 7001_ $$0P:(DE-HGF)0$$aRay-Chaudhuri, K.$$b13
000885838 7001_ $$0P:(DE-HGF)0$$aMartinez-Martin, Pablo$$b14
000885838 7001_ $$0P:(DE-HGF)0$$aFonoff, Erich Talamoni$$b15
000885838 7001_ $$0P:(DE-HGF)0$$aTimmermann, Lars$$b16
000885838 773__ $$0PERI:(DE-600)2404774-0$$a10.1016/j.brs.2020.09.019$$gVol. 13, no. 6, p. 1697 - 1705$$n6$$p1697 - 1705$$tBrain stimulation$$v13$$x1935-861X$$y2020
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