TY  - JOUR
AU  - Dafsari, Haidar S.
AU  - dos Santos Ghilardi, Maria Gabriela
AU  - Visser-Vandewalle, Veerle
AU  - Rizos, Alexandra
AU  - Ashkan, Keyoumars
AU  - Silverdale, Monty
AU  - Evans, Julian
AU  - Martinez, Raquel C. R.
AU  - Cury, Rubens G.
AU  - Jost, Stefanie T.
AU  - Barbe, Michael T.
AU  - Fink, Gereon R.
AU  - Antonini, Angelo
AU  - Ray-Chaudhuri, K.
AU  - Martinez-Martin, Pablo
AU  - Fonoff, Erich Talamoni
AU  - Timmermann, Lars
TI  - Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson’s disease
JO  - Brain stimulation
VL  - 13
IS  - 6
SN  - 1935-861X
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - FZJ-2020-04124
SP  - 1697 - 1705
PY  - 2020
AB  - BackgroundSubthalamic (STN) and pallidal (GPi) deep brain stimulation (DBS) improve quality of life, motor, and nonmotor symptoms (NMS) in advanced Parkinson’s disease (PD). However, few studies have compared their nonmotor effects.ObjectiveTo compare nonmotor effects of STN-DBS and GPi-DBS.MethodsIn this prospective, observational, multicenter study including 60 PD patients undergoing bilateral STN-DBS (n = 40) or GPi-DBS (n = 20), we examined PDQuestionnaire (PDQ), NMSScale (NMSS), Unified PD Rating Scale-activities of daily living, -motor impairment, -complications (UPDRS-II, –III, -IV), Hoehn&Yahr, Schwab&England Scale, and levodopa-equivalent daily dose (LEDD) preoperatively and at 6-month follow-up. Intra-group changes at follow-up were analyzed with Wilcoxon signed-rank or paired t-test, if parametric tests were applicable, and corrected for multiple comparisons. Inter-group differences were explored with Mann-Whitney-U/unpaired t-tests. Analyses were performed before and after propensity score matching which balanced out demographic and preoperative clinical characteristics. Strength of clinical changes was assessed with effect size.ResultsIn both groups, PDQ, UPDRS-II, -IV, Schwab&England Scale, and NMSS improved significantly at follow-up. STN-DBS was significantly better for LEDD reduction, GPi-DBS for UPDRS-IV. While NMSS total score outcomes were similar, explorative NMSS domain analyses revealed distinct profiles: Both targets improved sleep/fatigue and mood/cognition, but only STN-DBS the miscellaneous (pain/olfaction) and attention/memory and only GPi-DBS cardiovascular and sexual function domains.
LB  - PUB:(DE-HGF)16
C6  - pmid:33038595
UR  - <Go to ISI:>//WOS:000597945200035
DO  - DOI:10.1016/j.brs.2020.09.019
UR  - https://juser.fz-juelich.de/record/885838
ER  -