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@ARTICLE{Dafsari:885838,
      author       = {Dafsari, Haidar S. and dos Santos Ghilardi, Maria Gabriela
                      and Visser-Vandewalle, Veerle and Rizos, Alexandra and
                      Ashkan, Keyoumars and Silverdale, Monty and Evans, Julian
                      and Martinez, Raquel C. R. and Cury, Rubens G. and Jost,
                      Stefanie T. and Barbe, Michael T. and Fink, Gereon R. and
                      Antonini, Angelo and Ray-Chaudhuri, K. and Martinez-Martin,
                      Pablo and Fonoff, Erich Talamoni and Timmermann, Lars},
      title        = {{B}eneficial nonmotor effects of subthalamic and pallidal
                      neurostimulation in {P}arkinson’s disease},
      journal      = {Brain stimulation},
      volume       = {13},
      number       = {6},
      issn         = {1935-861X},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-04124},
      pages        = {1697 - 1705},
      year         = {2020},
      abstract     = {BackgroundSubthalamic (STN) and pallidal (GPi) deep brain
                      stimulation (DBS) improve quality of life, motor, and
                      nonmotor symptoms (NMS) in advanced Parkinson’s disease
                      (PD). However, few studies have compared their nonmotor
                      effects.ObjectiveTo compare nonmotor effects of STN-DBS and
                      GPi-DBS.MethodsIn this prospective, observational,
                      multicenter study including 60 PD patients undergoing
                      bilateral STN-DBS (n = 40) or GPi-DBS (n = 20), we examined
                      PDQuestionnaire (PDQ), NMSScale (NMSS), Unified PD Rating
                      Scale-activities of daily living, -motor impairment,
                      -complications (UPDRS-II, –III, -IV), $Hoehn\&Yahr,$
                      $Schwab\&England$ Scale, and levodopa-equivalent daily dose
                      (LEDD) preoperatively and at 6-month follow-up. Intra-group
                      changes at follow-up were analyzed with Wilcoxon signed-rank
                      or paired t-test, if parametric tests were applicable, and
                      corrected for multiple comparisons. Inter-group differences
                      were explored with Mann-Whitney-U/unpaired t-tests. Analyses
                      were performed before and after propensity score matching
                      which balanced out demographic and preoperative clinical
                      characteristics. Strength of clinical changes was assessed
                      with effect size.ResultsIn both groups, PDQ, UPDRS-II, -IV,
                      $Schwab\&England$ Scale, and NMSS improved significantly at
                      follow-up. STN-DBS was significantly better for LEDD
                      reduction, GPi-DBS for UPDRS-IV. While NMSS total score
                      outcomes were similar, explorative NMSS domain analyses
                      revealed distinct profiles: Both targets improved
                      sleep/fatigue and mood/cognition, but only STN-DBS the
                      miscellaneous (pain/olfaction) and attention/memory and only
                      GPi-DBS cardiovascular and sexual function domains.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33038595},
      UT           = {WOS:000597945200035},
      doi          = {10.1016/j.brs.2020.09.019},
      url          = {https://juser.fz-juelich.de/record/885838},
}