%0 Journal Article
%A Novak, Sanja
%A Zhang, Jing
%A Kentzinger, Emmanuel
%A Rücker, Ulrich
%A Portale, Giuseppe
%A Jung, Niklas
%A Jonas, Ulrich
%A Myung, Jin S.
%A Winkler, Roland G.
%A Gompper, Gerhard
%A Dhont, Jan K. G.
%A Stiakakis, Emmanuel
%T DNA Self-Assembly Mediated by Programmable Soft-Patchy Interactions
%J ACS nano
%V 14
%N 10
%@ 1936-086X
%C Washington, DC
%I Soc.
%M FZJ-2020-04162
%P 13524–13535
%D 2020
%X Adding shape and interaction anisotropy to a colloidal particle offers exquisitely tunable routes to engineer a rich assortment of complex-architected structures. Inspired by the hierarchical self-assembly concept with block copolymers and DNA liquid crystals and exploiting the unique assembly properties of DNA, we report here the construction and self-assembly of DNA-based soft-patchy anisotropic particles with a high degree of modularity in the system’s design. By programmable positioning of thermoresponsive polymeric patches on the backbone of a stiff DNA duplex with linear and star-shaped architecture, we reversibly drive the DNA from a disordered ensemble to a diverse array of long-range ordered multidimensional nanostructures with tunable lattice spacing, ranging from lamellar to bicontinuous double-gyroid and double-diamond cubic morphologies, through the alteration of temperature. Our results demonstrate that the proposed hierarchical self-assembly strategy can be applied to any kind of DNA nanoarchitecture, highlighting the design principles for integration of self-assembly concepts from the physics of liquid crystals, block copolymers, and patchy colloids into the continuously growing interdisciplinary research field of structural DNA nanotechnology.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 33048544
%U <Go to ISI:>//WOS:000586793400100
%R 10.1021/acsnano.0c05536
%U https://juser.fz-juelich.de/record/885886