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024 7 _ |a 10.1021/acsnano.0c05536
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100 1 _ |a Novak, Sanja
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245 _ _ |a DNA Self-Assembly Mediated by Programmable Soft-Patchy Interactions
260 _ _ |a Washington, DC
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520 _ _ |a Adding shape and interaction anisotropy to a colloidal particle offers exquisitely tunable routes to engineer a rich assortment of complex-architected structures. Inspired by the hierarchical self-assembly concept with block copolymers and DNA liquid crystals and exploiting the unique assembly properties of DNA, we report here the construction and self-assembly of DNA-based soft-patchy anisotropic particles with a high degree of modularity in the system’s design. By programmable positioning of thermoresponsive polymeric patches on the backbone of a stiff DNA duplex with linear and star-shaped architecture, we reversibly drive the DNA from a disordered ensemble to a diverse array of long-range ordered multidimensional nanostructures with tunable lattice spacing, ranging from lamellar to bicontinuous double-gyroid and double-diamond cubic morphologies, through the alteration of temperature. Our results demonstrate that the proposed hierarchical self-assembly strategy can be applied to any kind of DNA nanoarchitecture, highlighting the design principles for integration of self-assembly concepts from the physics of liquid crystals, block copolymers, and patchy colloids into the continuously growing interdisciplinary research field of structural DNA nanotechnology.
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773 _ _ |a 10.1021/acsnano.0c05536
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856 4 _ |y Published on 2020-10-13. Available in OpenAccess from 2021-10-13.
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856 4 _ |y Published on 2020-10-13. Available in OpenAccess from 2021-10-13.
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