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@ARTICLE{Imahorn:885963,
      author       = {Imahorn, Elias and Aushev, Magomet and Herms, Stefan and
                      Hoffmann, Per and Cichon, Sven and Reichelt, Julia and Itin,
                      Peter H. and Burger, Bettina},
      title        = {{G}ene expression is stable in a complete {CIB}1 knockout
                      keratinocyte model},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2020-04194},
      pages        = {14952},
      year         = {2020},
      abstract     = {Epidermodysplasia verruciformis (EV) is a genodermatosis
                      characterized by the inability of keratinocytes to control
                      cutaneous β-HPV infection and a high risk for non-melanoma
                      skin cancer (NMSC). Bi-allelic loss of function variants in
                      TMC6, TMC8, and CIB1 predispose to EV. The correlation
                      between these proteins and β-HPV infection is unclear. Its
                      elucidation will advance the understanding of HPV control in
                      human keratinocytes and development of NMSC. We generated a
                      cell culture model by CRISPR/Cas9-mediated deletion of CIB1
                      to study the function of CIB1 in keratinocytes. Nine CIB1
                      knockout and nine mock control clones were generated
                      originating from a human keratinocyte line. We observed
                      small changes in gene expression as a result of CIB1
                      knockout, which is consistent with the clearly defined
                      phenotype of EV patients. This suggests that the function of
                      human CIB1 in keratinocytes is limited and involves the
                      restriction of β-HPV. The presented model is useful to
                      investigate CIB1 interaction with β-HPV in future studies.},
      cin          = {INM-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32917957},
      UT           = {WOS:000572424900007},
      doi          = {10.1038/s41598-020-71889-9},
      url          = {https://juser.fz-juelich.de/record/885963},
}