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| 001 | 886066 | ||
| 005 | 20210113100822.0 | ||
| 024 | 7 | _ | |a 10.3390/pr8070780 |2 doi |
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| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Beck, Jürgen |0 0000-0002-4160-7760 |b 0 |
| 245 | _ | _ | |a Compartment Model of Mixing in a Bubble Trap and Its Impact on Chromatographic Separations |
| 260 | _ | _ | |a Basel |c 2020 |b MDPI |
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| 520 | _ | _ | |a Chromatography equipment includes hold-up volumes that are external to the packed bed and usually not considered in the development of chromatography models. These volumes can substantially contribute to band-broadening in the system and deteriorate the predicted performance. We selected a bubble trap of a pilot scale chromatography system as an example for a hold-up volume with a non-standard mixing behavior. In a worst-case scenario, the bubble trap is not properly flushed before elution, thus causing the significant band-broadening of the elution peak. We showed that the mixing of buffers with different densities in the bubble trap device can be accurately modeled using a simple compartment model. The model was calibrated at a wide range of flow rates and salt concentrations. The simulations were performed using the open-source software CADET, and all scripts and data are published with this manuscript. The results illustrate the importance of including external holdup volumes in chromatography modeling. The band-broadening effect of tubing, pumps, valves, detectors, frits, or any other zones with non-standard mixing behavior can be considered in very similar way |
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| 700 | 1 | _ | |a Heymann, William |0 P:(DE-Juel1)165915 |b 1 |
| 700 | 1 | _ | |a von Lieres, Eric |0 P:(DE-Juel1)129081 |b 2 |
| 700 | 1 | _ | |a Hahn, Rainer |0 0000-0001-5654-5032 |b 3 |e Corresponding author |
| 773 | _ | _ | |a 10.3390/pr8070780 |g Vol. 8, no. 7, p. 780 - |0 PERI:(DE-600)2720994-5 |n 7 |p 780 - |t Processes |v 8 |y 2020 |x 2227-9717 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/886066/files/processes-08-00780-v2.pdf |y OpenAccess |
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