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000886135 1001_ $$0P:(DE-HGF)0$$aWehrmann, Matthias$$b0
000886135 245__ $$aEngineered PQQ-Dependent Alcohol Dehydrogenase for the Oxidation of 5-(Hydroxymethyl)furoic Acid
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000886135 520__ $$aFuran-2,5-dicarboxylic acid (FDCA) is a bio-based platform chemical with the potential to replace terephthalic acid in the production of polymers. A critical step for enzymatic and whole-cell production of FDCA from 5-(hydroxymethyl)furfural (HMF) is the transformation of 5-(hydroxymethyl)furoic acid (HMFA) into 5-formylfuroic acid (FFA). Here, we establish periplasmic pyrroloquinoline quinone (PQQ)-dependent alcohol dehydrogenases (ADHs) as biocatalytic tools for the oxidation of HMFA, HMF, and 5-formylfurfural (FFF). Further, we identify several amino acid residues including the “lid loop” of the substrate channel as promising targets for future engineering steps toward a fully periplasmic oxidation pathway to FDCA.
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000886135 7001_ $$0P:(DE-HGF)0$$aElsayed, Eslam M.$$b1
000886135 7001_ $$00000-0002-4606-4961$$aKöbbing, Sebastian$$b2
000886135 7001_ $$0P:(DE-HGF)0$$aBendz, Laura$$b3
000886135 7001_ $$0P:(DE-HGF)0$$aLepak, Alexander$$b4
000886135 7001_ $$0P:(DE-HGF)0$$aSchwabe, Johannes$$b5
000886135 7001_ $$0P:(DE-Juel1)176653$$aWierckx, Nick$$b6
000886135 7001_ $$0P:(DE-HGF)0$$aBange, Gert$$b7$$eCorresponding author
000886135 7001_ $$00000-0003-2740-3769$$aKlebensberger, Janosch$$b8$$eCorresponding author
000886135 773__ $$0PERI:(DE-600)2584887-2$$a10.1021/acscatal.0c01789$$gVol. 10, no. 14, p. 7836 - 7842$$n14$$p7836 - 7842$$tACS catalysis$$v10$$x2155-5435$$y2020
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