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@ARTICLE{Wehrmann:886135,
      author       = {Wehrmann, Matthias and Elsayed, Eslam M. and Köbbing,
                      Sebastian and Bendz, Laura and Lepak, Alexander and Schwabe,
                      Johannes and Wierckx, Nick and Bange, Gert and
                      Klebensberger, Janosch},
      title        = {{E}ngineered {PQQ}-{D}ependent {A}lcohol {D}ehydrogenase
                      for the {O}xidation of 5-({H}ydroxymethyl)furoic {A}cid},
      journal      = {ACS catalysis},
      volume       = {10},
      number       = {14},
      issn         = {2155-5435},
      address      = {Washington, DC},
      publisher    = {ACS},
      reportid     = {FZJ-2020-04296},
      pages        = {7836 - 7842},
      year         = {2020},
      note         = {Biotechnologie 1},
      abstract     = {Furan-2,5-dicarboxylic acid (FDCA) is a bio-based platform
                      chemical with the potential to replace terephthalic acid in
                      the production of polymers. A critical step for enzymatic
                      and whole-cell production of FDCA from
                      5-(hydroxymethyl)furfural (HMF) is the transformation of
                      5-(hydroxymethyl)furoic acid (HMFA) into 5-formylfuroic acid
                      (FFA). Here, we establish periplasmic pyrroloquinoline
                      quinone (PQQ)-dependent alcohol dehydrogenases (ADHs) as
                      biocatalytic tools for the oxidation of HMFA, HMF, and
                      5-formylfurfural (FFF). Further, we identify several amino
                      acid residues including the “lid loop” of the substrate
                      channel as promising targets for future engineering steps
                      toward a fully periplasmic oxidation pathway to FDCA.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {581 - Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000551549800035},
      doi          = {10.1021/acscatal.0c01789},
      url          = {https://juser.fz-juelich.de/record/886135},
}