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| Hauptseite > Publikationsdatenbank > Engineered PQQ-Dependent Alcohol Dehydrogenase for the Oxidation of 5-(Hydroxymethyl)furoic Acid > print |
| Hauptseite > Publikationsdatenbank > Engineered PQQ-Dependent Alcohol Dehydrogenase for the Oxidation of 5-(Hydroxymethyl)furoic Acid > print |
| 001 | 886135 | ||
| 005 | 20210130010610.0 | ||
| 024 | 7 | _ | |a 10.1021/acscatal.0c01789 |2 doi |
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| 037 | _ | _ | |a FZJ-2020-04296 |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Wehrmann, Matthias |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Engineered PQQ-Dependent Alcohol Dehydrogenase for the Oxidation of 5-(Hydroxymethyl)furoic Acid |
| 260 | _ | _ | |a Washington, DC |c 2020 |b ACS |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Biotechnologie 1 |
| 520 | _ | _ | |a Furan-2,5-dicarboxylic acid (FDCA) is a bio-based platform chemical with the potential to replace terephthalic acid in the production of polymers. A critical step for enzymatic and whole-cell production of FDCA from 5-(hydroxymethyl)furfural (HMF) is the transformation of 5-(hydroxymethyl)furoic acid (HMFA) into 5-formylfuroic acid (FFA). Here, we establish periplasmic pyrroloquinoline quinone (PQQ)-dependent alcohol dehydrogenases (ADHs) as biocatalytic tools for the oxidation of HMFA, HMF, and 5-formylfurfural (FFF). Further, we identify several amino acid residues including the “lid loop” of the substrate channel as promising targets for future engineering steps toward a fully periplasmic oxidation pathway to FDCA. |
| 536 | _ | _ | |a 581 - Biotechnology (POF3-581) |0 G:(DE-HGF)POF3-581 |c POF3-581 |f POF III |x 0 |
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| 700 | 1 | _ | |a Elsayed, Eslam M. |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Köbbing, Sebastian |0 0000-0002-4606-4961 |b 2 |
| 700 | 1 | _ | |a Bendz, Laura |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Lepak, Alexander |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Schwabe, Johannes |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Wierckx, Nick |0 P:(DE-Juel1)176653 |b 6 |
| 700 | 1 | _ | |a Bange, Gert |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 700 | 1 | _ | |a Klebensberger, Janosch |0 0000-0003-2740-3769 |b 8 |e Corresponding author |
| 773 | _ | _ | |a 10.1021/acscatal.0c01789 |g Vol. 10, no. 14, p. 7836 - 7842 |0 PERI:(DE-600)2584887-2 |n 14 |p 7836 - 7842 |t ACS catalysis |v 10 |y 2020 |x 2155-5435 |
| 856 | 4 | _ | |y Published on 2020-06-09. Available in OpenAccess from 2021-06-09. |z StatID:(DE-HGF)0510 |u https://juser.fz-juelich.de/record/886135/files/Wierckx%20authorcopy_ACS%20Catalysis_An%20engineered%20PQQ-dependent%20HMFA.pdf |
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