000887719 001__ 887719
000887719 005__ 20210130010627.0
000887719 0247_ $$2doi$$a10.1101/2020.06.15.153254
000887719 0247_ $$2Handle$$a2128/26145
000887719 0247_ $$2altmetric$$aaltmetric:84091096
000887719 037__ $$aFZJ-2020-04376
000887719 1001_ $$0P:(DE-Juel1)178872$$aDong, Debo$$b0$$eCorresponding author
000887719 245__ $$aLinking Cerebellar Functional Gradients to Transdiagnostic Behavioral Dimensions of Psychopathology
000887719 260__ $$c2020
000887719 3367_ $$0PUB:(DE-HGF)25$$2PUB:(DE-HGF)$$aPreprint$$bpreprint$$mpreprint$$s1605280312_16530
000887719 3367_ $$2ORCID$$aWORKING_PAPER
000887719 3367_ $$028$$2EndNote$$aElectronic Article
000887719 3367_ $$2DRIVER$$apreprint
000887719 3367_ $$2BibTeX$$aARTICLE
000887719 3367_ $$2DataCite$$aOutput Types/Working Paper
000887719 520__ $$aHigh co-morbidity and substantial overlap across psychiatric disorders encourage a transition in psychiatry research from categorical to dimensional approaches that integrate neuroscience and psychopathology. Cerebellum is involved in a wide range of nonmotor cognitive functions and mental disorders. An important question thus centers on the extent to which cerebellar function can be linked to transdiagnostic dimensions of psychopathology. Here, this question is investigated using partial least squares to identify latent dimensions linking cerebellar connectome properties as assessed by macroscale spatial gradients of connectivity to a large set of clinical and behavioral measures in 198 participants across diagnostic categories. This analysis reveals significant correlated patterns of cerebellar connectivity gradients and behavioral measures that could be represented into four latent dimensions: general psychopathology, general lack of attention regulation, internalizing symptoms, and dysfunctional memory. Each dimension is associated with a distinct spatial pattern of cerebellar connectivity gradients. These findings highlight the relevance of cerebellar connectivity as a necessity for the study and classification of transdiagnostic dimensions of psychopathology.
000887719 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000887719 588__ $$aDataset connected to CrossRef
000887719 7001_ $$0P:(DE-HGF)0$$aGuell, Xavier$$b1
000887719 7001_ $$0P:(DE-Juel1)161225$$aGenon, Sarah$$b2
000887719 7001_ $$0P:(DE-HGF)0$$aWang, Yulin$$b3
000887719 7001_ $$0P:(DE-Juel1)171414$$aChen, Ji$$b4
000887719 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b5
000887719 7001_ $$0P:(DE-HGF)0$$aLuo, Cheng$$b6
000887719 7001_ $$0P:(DE-HGF)0$$aYao, Dezhong$$b7
000887719 773__ $$a10.1101/2020.06.15.153254
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/2020.06.15.153254v1.full.pdf$$yOpenAccess
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig1.tif$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig2.tif$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig3.tif$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig4.tif$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Manuscript.doc$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Supplementary%20information.doc$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Table%201.doc$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/2020.06.15.153254v1.full.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig1.gif?subformat=icon$$xicon$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig1.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig1.jpg?subformat=icon-180$$xicon-180$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig1.jpg?subformat=icon-640$$xicon-640$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig2.gif?subformat=icon$$xicon$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig2.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig2.jpg?subformat=icon-180$$xicon-180$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig2.jpg?subformat=icon-640$$xicon-640$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig3.gif?subformat=icon$$xicon$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig3.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig3.jpg?subformat=icon-180$$xicon-180$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig3.jpg?subformat=icon-640$$xicon-640$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig4.gif?subformat=icon$$xicon$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig4.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig4.jpg?subformat=icon-180$$xicon-180$$yRestricted
000887719 8564_ $$uhttps://juser.fz-juelich.de/record/887719/files/Fig4.jpg?subformat=icon-640$$xicon-640$$yRestricted
000887719 909CO $$ooai:juser.fz-juelich.de:887719$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000887719 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)178872$$aForschungszentrum Jülich$$b0$$kFZJ
000887719 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)161225$$aForschungszentrum Jülich$$b2$$kFZJ
000887719 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)171414$$aForschungszentrum Jülich$$b4$$kFZJ
000887719 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b5$$kFZJ
000887719 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000887719 9141_ $$y2020
000887719 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000887719 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000887719 920__ $$lyes
000887719 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000887719 980__ $$apreprint
000887719 980__ $$aVDB
000887719 980__ $$aUNRESTRICTED
000887719 980__ $$aI:(DE-Juel1)INM-7-20090406
000887719 9801_ $$aFullTexts