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@ARTICLE{Dong:887719,
      author       = {Dong, Debo and Guell, Xavier and Genon, Sarah and Wang,
                      Yulin and Chen, Ji and Eickhoff, Simon B. and Luo, Cheng and
                      Yao, Dezhong},
      title        = {{L}inking {C}erebellar {F}unctional {G}radients to
                      {T}ransdiagnostic {B}ehavioral {D}imensions of
                      {P}sychopathology},
      reportid     = {FZJ-2020-04376},
      year         = {2020},
      abstract     = {High co-morbidity and substantial overlap across
                      psychiatric disorders encourage a transition in psychiatry
                      research from categorical to dimensional approaches that
                      integrate neuroscience and psychopathology. Cerebellum is
                      involved in a wide range of nonmotor cognitive functions and
                      mental disorders. An important question thus centers on the
                      extent to which cerebellar function can be linked to
                      transdiagnostic dimensions of psychopathology. Here, this
                      question is investigated using partial least squares to
                      identify latent dimensions linking cerebellar connectome
                      properties as assessed by macroscale spatial gradients of
                      connectivity to a large set of clinical and behavioral
                      measures in 198 participants across diagnostic categories.
                      This analysis reveals significant correlated patterns of
                      cerebellar connectivity gradients and behavioral measures
                      that could be represented into four latent dimensions:
                      general psychopathology, general lack of attention
                      regulation, internalizing symptoms, and dysfunctional
                      memory. Each dimension is associated with a distinct spatial
                      pattern of cerebellar connectivity gradients. These findings
                      highlight the relevance of cerebellar connectivity as a
                      necessity for the study and classification of
                      transdiagnostic dimensions of psychopathology.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2020.06.15.153254},
      url          = {https://juser.fz-juelich.de/record/887719},
}