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@ARTICLE{Kutovyi:887747,
      author       = {Kutovyi, Yurii and Li, Jie and Zadorozhnyi, Ihor and
                      Hlukhova, Hanna and Boichuk, Nazarii and Yehorov, Dmytro and
                      Menger, Marcus and Vitusevich, Svetlana},
      title        = {{H}ighly {S}ensitive and {F}ast {D}etection of
                      {C}-{R}eactive {P}rotein and {T}roponin {B}iomarkers {U}sing
                      {L}iquid-gated {S}ingle {S}ilicon {N}anowire {B}iosensors},
      journal      = {MRS advances},
      volume       = {5},
      number       = {16},
      issn         = {2059-8521},
      address      = {Cambridge},
      publisher    = {Cambridge University Press},
      reportid     = {FZJ-2020-04404},
      pages        = {835-846},
      year         = {2020},
      abstract     = {C-reactive protein (CRP) and cardiac troponin I (cTnI)
                      biomolecules represent the earliest enzymes that appear in
                      the blood when a cardiac injury occurs. Real-time and
                      selective detection of these biomarkers is essential for the
                      prediction and detection of cardiovascular diseases at an
                      early stage. Here we report on the label-free specific
                      detection of both proteins at picomolar concentrations using
                      fabricated nanowire-based biosensors. We demonstrate a novel
                      functionalization technique based on the attachment of
                      dibenzocyclooctyne (DBCO)-linked troponin-specific aptamers
                      to azide-functionalized silicon (Si) nanowire (NW) surface.
                      Due to the fast and reliable immobilization of cTnI-specific
                      aptamers and CRP-specific antibodies on the Si NWs, the
                      fabricated devices can rapidly detect target biomolecules
                      demonstrating high sensitivity. We confirm the attachment of
                      proteins to the surface of Si NWs by atomic force microscopy
                      (AFM). Moreover, we demonstrate that nanowire structures of
                      different sizes enable the detection of biomarkers in a wide
                      concentration range (from 1 pg/ml to 1 µg/ml),
                      corresponding to CRP and cTnI elevation levels during the
                      early stage of disease formation.},
      cin          = {IBI-3},
      ddc          = {670},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000530306700005},
      doi          = {10.1557/adv.2020.60},
      url          = {https://juser.fz-juelich.de/record/887747},
}