000887874 001__ 887874 000887874 005__ 20210130010703.0 000887874 0247_ $$2doi$$a10.1176/appi.ajp.2020.19030331 000887874 0247_ $$2altmetric$$aaltmetric:84172457 000887874 0247_ $$2pmid$$apmid:32539527 000887874 0247_ $$2WOS$$aWOS:000564923300012 000887874 037__ $$aFZJ-2020-04496 000887874 082__ $$a150 000887874 1001_ $$0P:(DE-HGF)0$$aBoedhoe, Premika S. W.$$b0$$eCorresponding author 000887874 245__ $$aSubcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups 000887874 260__ $$a[Arlington, VA]$$bAmerican Psychiatric Association Publishing$$c2020 000887874 3367_ $$2DRIVER$$aarticle 000887874 3367_ $$2DataCite$$aOutput Types/Journal article 000887874 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1605539111_2432 000887874 3367_ $$2BibTeX$$aARTICLE 000887874 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000887874 3367_ $$00$$2EndNote$$aJournal Article 000887874 520__ $$aObjective: Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), andobsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently cooccur.We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positionedto investigate structural brain differences across these disorders.Methods: Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD(n=2,271), ASD (n=1,777), and OCD (n=2,323) from 151 cohorts worldwide were analyzed usingstandardized processing protocols. We examined subcortical volume, cortical thickness and surface areadifferences within a mega-analytical framework, pooling measures extracted from each cohort.Analyses were performed separately for children, adolescents, and adults using linear mixed-effectsmodels adjusting for age, sex and site (and intra-cranial volume (ICV) for subcortical and surface areameasures).Results: We found no shared differences among all three disorders, while shared differences betweenany two disorders did not survive multiple comparisons correction. Children with ADHD compared tothose with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children andadolescents with ADHD also had smaller ICV than controls and those with OCD or ASD. Adults withASD showed thicker frontal cortices compared to adult controls and other clinical groups. No OCDspecificdifferences across different age-groups and surface area differences among all disorders inchildhood and adulthood were observed. 000887874 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0 000887874 588__ $$aDataset connected to CrossRef 000887874 7001_ $$0P:(DE-HGF)0$$avan Rooij, Daan$$b1 000887874 7001_ $$0P:(DE-HGF)0$$aHoogman, Martine$$b2 000887874 7001_ $$0P:(DE-HGF)0$$aTwisk, Jos W. R.$$b3 000887874 7001_ $$0P:(DE-HGF)0$$aSchmaal, Lianne$$b4 000887874 7001_ $$0P:(DE-HGF)0$$aAbe, Yoshinari$$b5 000887874 7001_ $$0P:(DE-HGF)0$$aAlonso, Pino$$b6 000887874 7001_ $$0P:(DE-HGF)0$$aAmeis, Stephanie H.$$b7 000887874 7001_ $$0P:(DE-HGF)0$$aAnikin, Anatoly$$b8 000887874 7001_ $$0P:(DE-HGF)0$$aAnticevic, Alan$$b9 000887874 7001_ $$0P:(DE-HGF)0$$aArango, Celso$$b10 000887874 7001_ $$aArnold, Paul D.$$b11 000887874 7001_ $$aAsherson, Philip$$b12 000887874 7001_ $$aAssogna, Francesca$$b13 000887874 7001_ $$aAuzias, Guillaume$$b14 000887874 7001_ $$aBanaschewski, Tobias$$b15 000887874 7001_ $$aBaranov, Alexander$$b16 000887874 7001_ $$aBatistuzzo, Marcelo C.$$b17 000887874 7001_ $$aBaumeister, Sarah$$b18 000887874 7001_ $$aBaur-Streubel, Ramona$$b19 000887874 7001_ $$aBehrmann, Marlene$$b20 000887874 7001_ $$aBellgrove, Mark A.$$b21 000887874 7001_ $$aBenedetti, Francesco$$b22 000887874 7001_ $$aBeucke, Jan C.$$b23 000887874 7001_ $$aBiederman, Joseph$$b24 000887874 7001_ $$aBollettini, Irene$$b25 000887874 7001_ $$aBose, Anushree$$b26 000887874 7001_ $$aBralten, Janita$$b27 000887874 7001_ $$aBramati, Ivanei E.$$b28 000887874 7001_ $$aBrandeis, Daniel$$b29 000887874 7001_ $$aBrem, Silvia$$b30 000887874 7001_ $$aBrennan, Brian P.$$b31 000887874 7001_ $$aBusatto, Geraldo F.$$b32 000887874 7001_ $$aCalderoni, Sara$$b33 000887874 7001_ $$aCalvo, Anna$$b34 000887874 7001_ $$aCalvo, Rosa$$b35 000887874 7001_ $$aCastellanos, Francisco X.$$b36 000887874 7001_ $$aCercignani, Mara$$b37 000887874 7001_ $$aChaim-Avancini, Tiffany M.$$b38 000887874 7001_ $$aChantiluke, Kaylita C.$$b39 000887874 7001_ $$aCheng, Yuqi$$b40 000887874 7001_ $$aCho, Kang Ik K.$$b41 000887874 7001_ $$aChristakou, Anastasia$$b42 000887874 7001_ $$aCoghill, David$$b43 000887874 7001_ $$aConzelmann, Annette$$b44 000887874 7001_ $$aCubillo, Ana I.$$b45 000887874 7001_ $$aDale, Anders M.$$b46 000887874 7001_ $$aDallaspezia, Sara$$b47 000887874 7001_ $$aDaly, Eileen$$b48 000887874 7001_ $$aDenys, Damiaan$$b49 000887874 7001_ $$aDeruelle, Christine$$b50 000887874 7001_ $$aDi Martino, Adriana$$b51 000887874 7001_ $$aDinstein, Ilan$$b52 000887874 7001_ $$aDoyle, Alysa E.$$b53 000887874 7001_ $$aDurston, Sarah$$b54 000887874 7001_ $$aEarl, Eric A.$$b55 000887874 7001_ $$aEcker, Christine$$b56 000887874 7001_ $$aEhrlich, Stefan$$b57 000887874 7001_ $$aEly, Benjamin A.$$b58 000887874 7001_ $$aEpstein, Jeffrey N.$$b59 000887874 7001_ $$aEthofer, Thomas$$b60 000887874 7001_ $$aFair, Damien A.$$b61 000887874 7001_ $$aFallgatter, Andreas J.$$b62 000887874 7001_ $$aFaraone, Stephen V.$$b63 000887874 7001_ $$aFedor, Jennifer$$b64 000887874 7001_ $$aFeng, Xin$$b65 000887874 7001_ $$aFeusner, Jamie D.$$b66 000887874 7001_ $$aFitzgerald, Jackie$$b67 000887874 7001_ $$aFitzgerald, Kate D.$$b68 000887874 7001_ $$aFouche, Jean-Paul$$b69 000887874 7001_ $$aFreitag, Christine M.$$b70 000887874 7001_ $$aFridgeirsson, Egill A.$$b71 000887874 7001_ $$aFrodl, Thomas$$b72 000887874 7001_ $$aGabel, Matt C.$$b73 000887874 7001_ $$aGallagher, Louise$$b74 000887874 7001_ $$aGogberashvili, Tinatin$$b75 000887874 7001_ $$aGori, Ilaria$$b76 000887874 7001_ $$aGruner, Patricia$$b77 000887874 7001_ $$aGürsel, Deniz A.$$b78 000887874 7001_ $$aHaar, Shlomi$$b79 000887874 7001_ $$aHaavik, Jan$$b80 000887874 7001_ $$aHall, Geoffrey B.$$b81 000887874 7001_ $$aHarrison, Neil A.$$b82 000887874 7001_ $$aHartman, Catharina A.$$b83 000887874 7001_ $$aHeslenfeld, Dirk J.$$b84 000887874 7001_ $$aHirano, Yoshiyuki$$b85 000887874 7001_ $$aHoekstra, Pieter J.$$b86 000887874 7001_ $$aHoexter, Marcelo Q.$$b87 000887874 7001_ $$aHohmann, Sarah$$b88 000887874 7001_ $$aHøvik, Marie F.$$b89 000887874 7001_ $$aHu, Hao$$b90 000887874 7001_ $$aHuyser, Chaim$$b91 000887874 7001_ $$aJahanshad, Neda$$b92 000887874 7001_ $$aJalbrzikowski, Maria$$b93 000887874 7001_ $$aJames, Anthony$$b94 000887874 7001_ $$aJanssen, Joost$$b95 000887874 7001_ $$aJaspers-Fayer, Fern$$b96 000887874 7001_ $$aJernigan, Terry L.$$b97 000887874 7001_ $$aKapilushniy, Dmitry$$b98 000887874 7001_ $$aKardatzki, Bernd$$b99 000887874 7001_ $$aKarkashadze, Georgii$$b100 000887874 7001_ $$aKathmann, Norbert$$b101 000887874 7001_ $$aKaufmann, Christian$$b102 000887874 7001_ $$aKelly, Clare$$b103 000887874 7001_ $$aKhadka, Sabin$$b104 000887874 7001_ $$aKing, Joseph A.$$b105 000887874 7001_ $$aKoch, Kathrin$$b106 000887874 7001_ $$aKohls, Gregor$$b107 000887874 7001_ $$0P:(DE-Juel1)174172$$aKonrad, Kerstin$$b108 000887874 7001_ $$aKuno, Masaru$$b109 000887874 7001_ $$aKuntsi, Jonna$$b110 000887874 7001_ $$aKvale, Gerd$$b111 000887874 7001_ $$aKwon, Jun Soo$$b112 000887874 7001_ $$aLázaro, Luisa$$b113 000887874 7001_ $$aLera-Miguel, Sara$$b114 000887874 7001_ $$aLesch, Klaus-Peter$$b115 000887874 7001_ $$aHoekstra, Liesbeth$$b116 000887874 7001_ $$aLiu, Yanni$$b117 000887874 7001_ $$aLochner, Christine$$b118 000887874 7001_ $$aLouza, Mario R.$$b119 000887874 7001_ $$aLuna, Beatriz$$b120 000887874 7001_ $$aLundervold, Astri J.$$b121 000887874 7001_ $$aMalpas, Charles B.$$b122 000887874 7001_ $$aMarques, Paulo$$b123 000887874 7001_ $$aMarsh, Rachel$$b124 000887874 7001_ $$aMartínez-Zalacaín, Ignacio$$b125 000887874 7001_ $$aMataix-Cols, David$$b126 000887874 7001_ $$aMattos, Paulo$$b127 000887874 7001_ $$aMcCarthy, Hazel$$b128 000887874 7001_ $$aMcGrath, Jane$$b129 000887874 7001_ $$aMehta, Mitul A.$$b130 000887874 7001_ $$aMenchón, José M.$$b131 000887874 7001_ $$aMennes, Maarten$$b132 000887874 7001_ $$aMartinho, Mauricio Moller$$b133 000887874 7001_ $$aMoreira, Pedro S.$$b134 000887874 7001_ $$aMorer, Astrid$$b135 000887874 7001_ $$aMorgado, Pedro$$b136 000887874 7001_ $$aMuratori, Filippo$$b137 000887874 7001_ $$aMurphy, Clodagh M.$$b138 000887874 7001_ $$aMurphy, Declan G. M.$$b139 000887874 7001_ $$aNakagawa, Akiko$$b140 000887874 7001_ $$aNakamae, Takashi$$b141 000887874 7001_ $$aNakao, Tomohiro$$b142 000887874 7001_ $$aNamazova-Baranova, Leyla$$b143 000887874 7001_ $$aNarayanaswamy, Janardhanan C.$$b144 000887874 7001_ $$aNicolau, Rosa$$b145 000887874 7001_ $$aNigg, Joel T.$$b146 000887874 7001_ $$aNovotny, Stephanie E.$$b147 000887874 7001_ $$aNurmi, Erika L.$$b148 000887874 7001_ $$aWeiss, Eileen Oberwelland$$b149 000887874 7001_ $$aO’Gorman Tuura, Ruth L.$$b150 000887874 7001_ $$aO’Hearn, Kirsten$$b151 000887874 7001_ $$aO’Neill, Joseph$$b152 000887874 7001_ $$aOosterlaan, Jaap$$b153 000887874 7001_ $$aOranje, Bob$$b154 000887874 7001_ $$aPaloyelis, Yannis$$b155 000887874 7001_ $$aParellada, Mara$$b156 000887874 7001_ $$aPauli, Paul$$b157 000887874 7001_ $$aPerriello, Chris$$b158 000887874 7001_ $$aPiacentini, John$$b159 000887874 7001_ $$aPiras, Fabrizio$$b160 000887874 7001_ $$aPiras, Federica$$b161 000887874 7001_ $$aPlessen, Kerstin J.$$b162 000887874 7001_ $$aPuig, Olga$$b163 000887874 7001_ $$aRamos-Quiroga, J. Antoni$$b164 000887874 7001_ $$aReddy, Y. C. Janardhan$$b165 000887874 7001_ $$aReif, Andreas$$b166 000887874 7001_ $$aReneman, Liesbeth$$b167 000887874 7001_ $$aRetico, Alessandra$$b168 000887874 7001_ $$aRosa, Pedro G. P.$$b169 000887874 7001_ $$aRubia, Katya$$b170 000887874 7001_ $$aRus, Oana Georgiana$$b171 000887874 7001_ $$aSakai, Yuki$$b172 000887874 7001_ $$aSchrantee, Anouk$$b173 000887874 7001_ $$aSchwarz, Lena$$b174 000887874 7001_ $$aSchweren, Lizanne J. S.$$b175 000887874 7001_ $$aSeitz, Jochen$$b176 000887874 7001_ $$aShaw, Philip$$b177 000887874 7001_ $$aShook, Devon$$b178 000887874 7001_ $$aSilk, Tim J.$$b179 000887874 7001_ $$aSimpson, H. Blair$$b180 000887874 7001_ $$aSkokauskas, Norbert$$b181 000887874 7001_ $$aSoliva Vila, Juan Carlos$$b182 000887874 7001_ $$aSolovieva, Anastasia$$b183 000887874 7001_ $$aSoreni, Noam$$b184 000887874 7001_ $$aSoriano-Mas, Carles$$b185 000887874 7001_ $$aSpalletta, Gianfranco$$b186 000887874 7001_ $$aStern, Emily R.$$b187 000887874 7001_ $$aStevens, Michael C.$$b188 000887874 7001_ $$aStewart, S. Evelyn$$b189 000887874 7001_ $$aSudre, Gustavo$$b190 000887874 7001_ $$aSzeszko, Philip R.$$b191 000887874 7001_ $$aTamm, Leanne$$b192 000887874 7001_ $$aTaylor, Margot J.$$b193 000887874 7001_ $$aTolin, David F.$$b194 000887874 7001_ $$aTosetti, Michela$$b195 000887874 7001_ $$aTovar-Moll, Fernanda$$b196 000887874 7001_ $$aTsuchiyagaito, Aki$$b197 000887874 7001_ $$avan Erp, Theo G. M.$$b198 000887874 7001_ $$avan Wingen, Guido A.$$b199 000887874 7001_ $$aVance, Alasdair$$b200 000887874 7001_ $$aVenkatasubramanian, Ganesan$$b201 000887874 7001_ $$aVilarroya, Oscar$$b202 000887874 7001_ $$aVives-Gilabert, Yolanda$$b203 000887874 7001_ $$0P:(DE-Juel1)177845$$avon Polier, Georg G.$$b204 000887874 7001_ $$aWalitza, Susanne$$b205 000887874 7001_ $$aWallace, Gregory L.$$b206 000887874 7001_ $$aWang, Zhen$$b207 000887874 7001_ $$aWolfers, Thomas$$b208 000887874 7001_ $$aYoncheva, Yuliya N.$$b209 000887874 7001_ $$aYun, Je-Yeon$$b210 000887874 7001_ $$aZanetti, Marcus V.$$b211 000887874 7001_ $$aZhou, Fengfeng$$b212 000887874 7001_ $$aZiegler, Georg C.$$b213 000887874 7001_ $$aZierhut, Kathrin C.$$b214 000887874 7001_ $$aZwiers, Marcel P.$$b215 000887874 7001_ $$aThompson, Paul M.$$b216 000887874 7001_ $$aStein, Dan J.$$b217 000887874 7001_ $$aBuitelaar, Jan$$b218 000887874 7001_ $$aFranke, Barbara$$b219 000887874 7001_ $$avan den Heuvel, Odile A.$$b220 000887874 773__ $$0PERI:(DE-600)2960270-1$$a10.1176/appi.ajp.2020.19030331$$n9$$p834-843$$tThe American journal of psychiatry$$v777$$x2474-4662$$y2020 000887874 8564_ $$uhttps://juser.fz-juelich.de/record/887874/files/Boedhoe_van%20Rooij_etal_2020_AmJPsych_2ndRevision_submitted_accepted.pdf$$yRestricted 000887874 909CO $$ooai:juser.fz-juelich.de:887874$$pVDB 000887874 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)174172$$aForschungszentrum Jülich$$b108$$kFZJ 000887874 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177845$$aForschungszentrum Jülich$$b204$$kFZJ 000887874 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0 000887874 9141_ $$y2020 000887874 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-09-02 000887874 920__ $$lyes 000887874 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0 000887874 980__ $$ajournal 000887874 980__ $$aVDB 000887874 980__ $$aI:(DE-Juel1)INM-7-20090406 000887874 980__ $$aUNRESTRICTED