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| 005 | 20210130010703.0 | ||
| 024 | 7 | _ | |a 10.1176/appi.ajp.2020.19030331 |2 doi |
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| 024 | 7 | _ | |a pmid:32539527 |2 pmid |
| 024 | 7 | _ | |a WOS:000564923300012 |2 WOS |
| 037 | _ | _ | |a FZJ-2020-04496 |
| 082 | _ | _ | |a 150 |
| 100 | 1 | _ | |a Boedhoe, Premika S. W. |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups |
| 260 | _ | _ | |a [Arlington, VA] |c 2020 |b American Psychiatric Association Publishing |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1605539111_2432 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Objective: Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), andobsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently cooccur.We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positionedto investigate structural brain differences across these disorders.Methods: Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD(n=2,271), ASD (n=1,777), and OCD (n=2,323) from 151 cohorts worldwide were analyzed usingstandardized processing protocols. We examined subcortical volume, cortical thickness and surface areadifferences within a mega-analytical framework, pooling measures extracted from each cohort.Analyses were performed separately for children, adolescents, and adults using linear mixed-effectsmodels adjusting for age, sex and site (and intra-cranial volume (ICV) for subcortical and surface areameasures).Results: We found no shared differences among all three disorders, while shared differences betweenany two disorders did not survive multiple comparisons correction. Children with ADHD compared tothose with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children andadolescents with ADHD also had smaller ICV than controls and those with OCD or ASD. Adults withASD showed thicker frontal cortices compared to adult controls and other clinical groups. No OCDspecificdifferences across different age-groups and surface area differences among all disorders inchildhood and adulthood were observed. |
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| 773 | _ | _ | |a 10.1176/appi.ajp.2020.19030331 |0 PERI:(DE-600)2960270-1 |n 9 |p 834-843 |t The American journal of psychiatry |v 777 |y 2020 |x 2474-4662 |
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