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@ARTICLE{RincnMontes:887905,
      author       = {Rincón Montes, V. and Gehlen, Jana and Ingebrandt, S. and
                      Mokwa, W. and Walter, P. and Müller, Frank and
                      Offenhäusser, A.},
      title        = {{D}evelopment and in vitro validation of flexible
                      intraretinal probes},
      journal      = {Scientific reports},
      volume       = {10},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2020-04511},
      pages        = {19836},
      year         = {2020},
      abstract     = {The efforts to improve the treatment efficacy in blind
                      patients with retinal degenerative diseases would greatly
                      benefit from retinal activity feedback, which is lacking in
                      current retinal implants. While the door for a bidirectional
                      communication device that stimulates and records
                      intraretinally has been opened by the recent use of
                      silicon-based penetrating probes, the biological impact
                      induced by the insertion of such rigid devices is still
                      unknown. Here, we developed for the first time, flexible
                      intraretinal probes and validated in vitro the acute
                      biological insertion impact in mouse retinae compared to
                      standard silicon-based probes. Our results show that probes
                      based on flexible materials, such as polyimide and
                      parylene-C, in combination with a narrow shank design 50 µm
                      wide and 7 µm thick, and the use of insertion speeds as
                      high as 187.5 µm/s will successfully penetrate the retina,
                      reduce the footprint of the insertion to roughly 2 times the
                      cross-section of the probe, and induce low dead cell counts,
                      while keeping the vitality of the tissue and recording the
                      neural activity at different depths.},
      cin          = {IBI-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-1-20200312},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33199768},
      UT           = {WOS:000595259200008},
      doi          = {10.1038/s41598-020-76582-5},
      url          = {https://juser.fz-juelich.de/record/887905},
}