Hauptseite > Publikationsdatenbank > Chimpanzee Brain Morphometry Utilizing Standardized MRI Preprocessing and Macroanatomical Annotations > print

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005     20210130010709.0
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100 1 _ |a Vickery, Sam
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245 _ _ |a Chimpanzee Brain Morphometry Utilizing Standardized MRI Preprocessing and Macroanatomical Annotations
260 _ _ |a Cambridge
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520 _ _ |a Chimpanzees are among the closest living relatives to humans and, as such, provide a crucial comparative model for investigating primate brain evolution. In recent years, human brain mapping has strongly benefited from enhanced computational models and image processing pipelines that could also improve data analyses in animals by using species-specific templates. In this study, we use structural MRI data from the National Chimpanzee Brain Resource (NCBR) to develop the chimpanzee brain reference template Juna.Chimp for spatial registration and the macro-anatomical brain parcellation Davi130 for standardized whole-brain analysis. Additionally, we introduce a ready-to-use image processing pipeline built upon the CAT12 toolbox in SPM12, implementing a standard human image preprocessing framework in chimpanzees. Applying this approach to data from 178 subjects, we find strong evidence for age-related GM atrophy in multiple regions of the chimpanzee brain, as well as, a human-like anterior-posterior pattern of hemi-spheric asymmetry in medial chimpanzee brain regions.
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700 1 _ |a Hopkins, William D.
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700 1 _ |a Sherwood, Chet C.
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700 1 _ |a Schapiro, Steven J.
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700 1 _ |a Latzman, Robert D.
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700 1 _ |a Caspers, Svenja
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700 1 _ |a Gaser, Christian
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700 1 _ |a Eickhoff, Simon B.
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700 1 _ |a Dahnke, Robert
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700 1 _ |a Hoffstaedter, Felix
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773 _ _ |a 10.1101/2020.04.20.046680
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