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@ARTICLE{Lenyk:887940,
author = {Lenyk, Bohdan and Figueroa‐Miranda, Gabriela and
Pavlushko, Ivan and Lo, Young and Tanner, Julian A. and
Offenhäusser, Andreas and Mayer, Dirk},
title = {{D}ual‐{T}ransducer {M}alaria {A}ptasensor {C}ombining
{E}lectrochemical {I}mpedance and {S}urface {P}lasmon
{P}olariton {D}etection on {G}old {N}anohole {A}rrays},
journal = {ChemElectroChem},
volume = {7},
number = {22},
issn = {2196-0216},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {FZJ-2020-04532},
pages = {4594 - 4600},
year = {2020},
abstract = {Two transducer principles are combined in one aptamer
biosensor (aptasensor) by simultaneously performing
electrochemical impedance spectroscopy (EIS) and surface
plasmon polariton (SPP) detection of a malaria biomarker. A
thin gold film perforated with nanohole arrays is modified
with small and highly charged aptamer receptors and utilized
for the detection of Plasmodium falciparum lactate
dehydrogenase (PfLDH), the main biomarker of malaria.
Monitoring the same analyte binding events by two
independent transduction principles not only corroborates
the in situ detection, but also covers a concentration
range of six orders of magnitude (1 pM–1 μM). The EIS
method is highly sensitive to low concentrations of PfLDH
(1 pM–100 nM), whereas SPP is sensitive to higher
concentrations of the target (10 nM–1 μM), owing to
either high interfacial or more bulk sensitivity,
respectively. Thus, we propose the dual‐transducer
aptasensor based on gold nanohole arrays as a platform for a
broad dynamic concentration range and reliable detection.},
cin = {IBI-3},
ddc = {540},
cid = {I:(DE-Juel1)IBI-3-20200312},
pnm = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
pid = {G:(DE-HGF)POF3-523},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000593989300010},
doi = {10.1002/celc.202001212},
url = {https://juser.fz-juelich.de/record/887940},
}