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@MISC{PalomeroGallagher:887984,
      author       = {Palomero-Gallagher, Nicola},
      title        = {{I}n vitro binding characterization of [³{H}] {LY}2119620
                      for the muscarinic cholinergic receptor type 2},
      publisher    = {EBRAINS},
      reportid     = {FZJ-2020-04562},
      year         = {2020},
      abstract     = {Modern modelling and simulation approaches have been
                      exploited to pinpoint and design more potent and specific
                      ligands and allosteric modulators which can be used not only
                      for research, but also for diagnostic and even therapeutic
                      purposes. A crucial component of the ligand development
                      program is the experimental validation of the accuracy and
                      reliability of candidate compounds. We here present the data
                      of the in vitro binding characterization of the novel ligand
                      [3H] LY2119620, an allosteric modulator of the cholinergic
                      muscarinic receptor type 2 (M2) obtained from the primary
                      motor cortex (M1), the primary somatosensory cortex (S1),
                      the hippocampus (Hip), the striatum (Str), and the
                      cerebellum (Cb) of six adult rat brains. For each brain
                      regions, the dataset comprises (i) the cross-subject average
                      density and standard deviation of the M2 receptor (in
                      fmol/mg), as determined by labelling with [3H] LY2119620,
                      and (ii) the corresponding dissociation constant (KD) of
                      this labelling agent (in nM).},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / HBP
                      SGA2 - Human Brain Project Specific Grant Agreement 2
                      (785907) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF3-574 / G:(EU-Grant)785907 /
                      G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)32},
      doi          = {10.25493/J0FD-1M9},
      url          = {https://juser.fz-juelich.de/record/887984},
}