%0 Journal Article
%A Paquola, Casey
%A Benkarim, Oualid
%A DeKraker, Jordan
%A Larivière, Sara
%A Frässle, Stefan
%A Royer, Jessica
%A Tavakol, Shahin
%A Valk, Sofie
%A Bernasconi, Andrea
%A Bernasconi, Neda
%A Khan, Ali
%A Evans, Alan C
%A Razi, Adeel
%A Smallwood, Jonathan
%A Bernhardt, Boris C
%T Convergence of cortical types and functional motifs in the human mesiotemporal lobe
%J eLife
%V 9
%@ 2050-084X
%C Cambridge
%I eLife Sciences Publications
%M FZJ-2020-04607
%P e60673
%D 2020
%X The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Projecting the histology-derived MTL model to in-vivo functional MRI, we furthermore determined how its cytoarchitecture underpins its intrinsic effective connectivity and association to large-scale networks. Here, the cytoarchitectural gradient was found to underpin intrinsic effective connectivity of the MTL, but patterns differed along the anterior-posterior axis. Moreover, while the iso-to-allocortical gradient parametrically represented the multiple-demand relative to task-negative networks, anterior-posterior gradients represented transmodal versus unimodal networks. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organisation.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33146610
%U <Go to ISI:>//WOS:000592792400001
%R 10.7554/eLife.60673
%U https://juser.fz-juelich.de/record/888029