TY  - JOUR
AU  - Paquola, Casey
AU  - Benkarim, Oualid
AU  - DeKraker, Jordan
AU  - Larivière, Sara
AU  - Frässle, Stefan
AU  - Royer, Jessica
AU  - Tavakol, Shahin
AU  - Valk, Sofie
AU  - Bernasconi, Andrea
AU  - Bernasconi, Neda
AU  - Khan, Ali
AU  - Evans, Alan C
AU  - Razi, Adeel
AU  - Smallwood, Jonathan
AU  - Bernhardt, Boris C
TI  - Convergence of cortical types and functional motifs in the human mesiotemporal lobe
JO  - eLife
VL  - 9
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - FZJ-2020-04607
SP  - e60673
PY  - 2020
AB  - The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Projecting the histology-derived MTL model to in-vivo functional MRI, we furthermore determined how its cytoarchitecture underpins its intrinsic effective connectivity and association to large-scale networks. Here, the cytoarchitectural gradient was found to underpin intrinsic effective connectivity of the MTL, but patterns differed along the anterior-posterior axis. Moreover, while the iso-to-allocortical gradient parametrically represented the multiple-demand relative to task-negative networks, anterior-posterior gradients represented transmodal versus unimodal networks. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organisation.
LB  - PUB:(DE-HGF)16
C6  - pmid:33146610
UR  - <Go to ISI:>//WOS:000592792400001
DO  - DOI:10.7554/eLife.60673
UR  - https://juser.fz-juelich.de/record/888029
ER  -