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@ARTICLE{Paquola:888029,
author = {Paquola, Casey and Benkarim, Oualid and DeKraker, Jordan
and Larivière, Sara and Frässle, Stefan and Royer, Jessica
and Tavakol, Shahin and Valk, Sofie and Bernasconi, Andrea
and Bernasconi, Neda and Khan, Ali and Evans, Alan C and
Razi, Adeel and Smallwood, Jonathan and Bernhardt, Boris C},
title = {{C}onvergence of cortical types and functional motifs in
the human mesiotemporal lobe},
journal = {eLife},
volume = {9},
issn = {2050-084X},
address = {Cambridge},
publisher = {eLife Sciences Publications},
reportid = {FZJ-2020-04607},
pages = {e60673},
year = {2020},
abstract = {The mesiotemporal lobe (MTL) is implicated in many
cognitive processes, is compromised in numerous brain
disorders, and exhibits a gradual cytoarchitectural
transition from six-layered parahippocampal isocortex to
three-layered hippocampal allocortex. Leveraging an
ultra-high-resolution histological reconstruction of a human
brain, our study showed that the dominant axis of MTL
cytoarchitectural differentiation follows the
iso-to-allocortical transition and depth-specific variations
in neuronal density. Projecting the histology-derived MTL
model to in-vivo functional MRI, we furthermore determined
how its cytoarchitecture underpins its intrinsic effective
connectivity and association to large-scale networks. Here,
the cytoarchitectural gradient was found to underpin
intrinsic effective connectivity of the MTL, but patterns
differed along the anterior-posterior axis. Moreover, while
the iso-to-allocortical gradient parametrically represented
the multiple-demand relative to task-negative networks,
anterior-posterior gradients represented transmodal versus
unimodal networks. Our findings establish that the
combination of micro- and macrostructural features allow the
MTL to represent dominant motifs of whole-brain functional
organisation.},
cin = {INM-7},
ddc = {600},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:33146610},
UT = {WOS:000592792400001},
doi = {10.7554/eLife.60673},
url = {https://juser.fz-juelich.de/record/888029},
}