% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Peng:888189,
      author       = {Peng, Ke and Preisig, Natalie and Sottmann, Thomas and
                      Stubenrauch, Cosima},
      title        = {{F}ormulation of {G}elled {N}on-toxic {B}icontinuous
                      {M}icroemulsions {S}tabilized by {H}ighly {E}fficient
                      {A}lkanoyl {M}ethylglucamides},
      journal      = {Langmuir},
      volume       = {36},
      number       = {42},
      issn         = {1520-5827},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2020-04751},
      pages        = {12692 - 12701},
      year         = {2020},
      abstract     = {Gelled non-toxic bicontinuous microemulsions have a great
                      potential for transdermal drug delivery as the microemulsion
                      facilitates the solubilization of both hydrophilic and
                      hydrophobic drugs, while the gel network provides mechanical
                      stability and thus an easy application on the skin. In our
                      previous study, we formulated a gelled non-toxic
                      bicontinuous microemulsion: we gelled the system H2O – IPM
                      – Plantacare 1200 UP (C12G1.4) – 1,2-octanediol with the
                      low molecular weight organogelator
                      1,3:2,4-dibenzylidene-D-sorbitol (DBS). However, a large
                      amount of Plantacare 1200 UP (12 $wt.\%)$ is needed to form
                      a bicontinuous microemulsion. To solve this problem, we
                      studied a new class of surfactants, namely alkanoyl
                      methylglucamides (MEGA), which has been rarely used for the
                      formulation of microemulsions. The phase behavior of
                      MEGA-8/10, MEGA-12/14-PC and MEGA-12/14-HC was compared with
                      that of alkyl polyglucosides. We found that even with 2
                      $wt.\%$ MEGA-12/14-HC a bicontinuous microemulsion can be
                      formed, which is 1/6 of the amount of Plantacare 1200 UP.
                      The bicontinuous microstructure of the non-toxic
                      microemulsion H2O – IPM – MEGA-12/14-HC –
                      1,2-octanediol was confirmed by small-angle neutron
                      scattering (SANS). Furthermore, the phase boundaries
                      remained unchanged when gelled by DBS. The rheological
                      properties of the gel were studied by oscillatory shear
                      rheometry. Finally, FFEM images show the coexistence of gel
                      fibers and bicontinuous oil and water domains. These results
                      suggest that the new gelled non-toxic bicontinuous
                      microemulsion is an orthogonal self-assembled system.},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33064496},
      UT           = {WOS:000586785000026},
      doi          = {10.1021/acs.langmuir.0c02314},
      url          = {https://juser.fz-juelich.de/record/888189},
}