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000888237 245__ $$aViral rhodopsins 1 are an unique family of light-gated cation channels
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000888237 520__ $$aPhytoplankton is the base of the marine food chain as well as oxygen and carbon cycles and thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses that infect phytoplankton organisms and regulate the phytoplankton dynamics encompass genes of rhodopsins of two distinct families. Here, we present a functional and structural characterization of two proteins of viral rhodopsin group 1, OLPVR1 and VirChR1. Functional analysis of VirChR1 shows that it is a highly selective, Na+/K+-conducting channel and, in contrast to known cation channelrhodopsins, it is impermeable to Ca2+ ions. We show that, upon illumination, VirChR1 is able to drive neural firing. The 1.4 Å resolution structure of OLPVR1 reveals remarkable differences from the known channelrhodopsins and a unique ion-conducting pathway. Thus, viral rhodopsins 1 represent a unique, large group of light-gated channels (viral channelrhodopsins, VirChR1s). In nature, VirChR1s likely mediate phototaxis of algae enhancing the host anabolic processes to support virus reproduction, and therefore, might play a major role in global phytoplankton dynamics. Moreover, VirChR1s have unique potential for optogenetics as they lack possibly noxious Ca2+ permeability.
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000888237 7001_ $$0P:(DE-Juel1)169220$$aKovalev, Kirill$$b2
000888237 7001_ $$00000-0003-0285-5232$$aRankovic, Vladan$$b3
000888237 7001_ $$0P:(DE-Juel1)131949$$aBalandin, Taras$$b4
000888237 7001_ $$00000-0001-7945-2218$$aSoloviov, Dmytro$$b5
000888237 7001_ $$0P:(DE-Juel1)131953$$aBratanov, Dmitry$$b6
000888237 7001_ $$0P:(DE-Juel1)176117$$aSavelyeva, Ekaterina$$b7
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000888237 7001_ $$0P:(DE-Juel1)176102$$aVaganova, Svetlana$$b10
000888237 7001_ $$0P:(DE-HGF)0$$aAstashkin, Roman$$b11
000888237 7001_ $$0P:(DE-HGF)0$$aChizhov, Igor$$b12
000888237 7001_ $$0P:(DE-HGF)0$$aYutin, Natalia$$b13
000888237 7001_ $$0P:(DE-HGF)0$$aRulev, Maksim$$b14
000888237 7001_ $$0P:(DE-HGF)0$$aPopov, Alexander$$b15
000888237 7001_ $$00000-0001-5981-6416$$aEria-Oliveira, Ana-Sofia$$b16
000888237 7001_ $$00000-0002-7719-1875$$aRokitskaya, Tatiana$$b17
000888237 7001_ $$0P:(DE-HGF)0$$aMager, Thomas$$b18
000888237 7001_ $$0P:(DE-HGF)0$$aAntonenko, Yuri$$b19
000888237 7001_ $$00000-0003-1393-0103$$aRosselli, Riccardo$$b20
000888237 7001_ $$0P:(DE-HGF)0$$aArmeev, Grigoriy$$b21
000888237 7001_ $$00000-0002-5137-303X$$aShaitan, Konstantin$$b22
000888237 7001_ $$0P:(DE-HGF)0$$aVivaudou, Michel$$b23
000888237 7001_ $$0P:(DE-Juel1)131957$$aBüldt, Georg$$b24
000888237 7001_ $$0P:(DE-HGF)0$$aRogachev, Andrey$$b25
000888237 7001_ $$00000-0002-9809-2059$$aRodriguez-Valera, Francisco$$b26
000888237 7001_ $$0P:(DE-HGF)0$$aKirpichnikov, Mikhail$$b27
000888237 7001_ $$00000-0001-7145-0533$$aMoser, Tobias$$b28
000888237 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b29
000888237 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b30
000888237 7001_ $$00000-0003-3943-8299$$aKoonin, Eugene$$b31
000888237 7001_ $$0P:(DE-HGF)0$$aBamberg, Ernst$$b32
000888237 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b33$$eCorresponding author
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