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| Hauptseite > Publikationsdatenbank > Viral rhodopsins 1 are an unique family of light-gated cation channels > print |
| Hauptseite > Publikationsdatenbank > Viral rhodopsins 1 are an unique family of light-gated cation channels > print |
| 001 | 888237 | ||
| 005 | 20220930130258.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-020-19457-7 |2 doi |
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| 100 | 1 | _ | |a Zabelskii, Dmitrii |0 P:(DE-Juel1)176570 |b 0 |u fzj |
| 245 | _ | _ | |a Viral rhodopsins 1 are an unique family of light-gated cation channels |
| 260 | _ | _ | |a [London] |c 2020 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Phytoplankton is the base of the marine food chain as well as oxygen and carbon cycles and thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses that infect phytoplankton organisms and regulate the phytoplankton dynamics encompass genes of rhodopsins of two distinct families. Here, we present a functional and structural characterization of two proteins of viral rhodopsin group 1, OLPVR1 and VirChR1. Functional analysis of VirChR1 shows that it is a highly selective, Na+/K+-conducting channel and, in contrast to known cation channelrhodopsins, it is impermeable to Ca2+ ions. We show that, upon illumination, VirChR1 is able to drive neural firing. The 1.4 Å resolution structure of OLPVR1 reveals remarkable differences from the known channelrhodopsins and a unique ion-conducting pathway. Thus, viral rhodopsins 1 represent a unique, large group of light-gated channels (viral channelrhodopsins, VirChR1s). In nature, VirChR1s likely mediate phototaxis of algae enhancing the host anabolic processes to support virus reproduction, and therefore, might play a major role in global phytoplankton dynamics. Moreover, VirChR1s have unique potential for optogenetics as they lack possibly noxious Ca2+ permeability. |
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| 773 | _ | _ | |a 10.1038/s41467-020-19457-7 |g Vol. 11, no. 1, p. 5707 |0 PERI:(DE-600)2553671-0 |n 1 |p 5707 |t Nature Communications |v 11 |y 2020 |x 2041-1723 |
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