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@ARTICLE{PetrySchmelzer:888240,
      author       = {Petry‐Schmelzer, Jan Niklas and Jergas, Hannah and Thies,
                      Tabea and Steffen, Julia K. and Reker, Paul and Dafsari,
                      Haidar S. and Mücke, Doris and Fink, Gereon R. and
                      Visser‐Vandewalle, Veerle and Dembek, Till A. and Barbe,
                      Michael T.},
      title        = {{N}etwork fingerprint of stimulation‐induced speech
                      impairment in essential tremor},
      journal      = {Annals of neurology},
      volume       = {89},
      number       = {2},
      issn         = {1531-8249},
      address      = {Hoboken, NJ},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2020-04789},
      pages        = {315-326},
      year         = {2021},
      abstract     = {ObjectiveThis study was undertaken to gain insights into
                      structural networks associated with stimulation‐induced
                      dysarthria (SID) and to predict stimulation‐induced
                      worsening of intelligibility in essential tremor patients
                      with bilateral thalamic deep brain stimulation
                      (DBS).MethodsMonopolar reviews were conducted in 14
                      essential tremor patients. Testing included determination of
                      SID thresholds, intelligibility ratings, and a fast syllable
                      repetition task. Volumes of tissue activated (VTAs) were
                      calculated to identify discriminative fibers for
                      stimulation‐induced worsening of intelligibility in a
                      structural connectome. The resulting fiber‐based atlas
                      structure was then validated in a leave‐one‐out
                      design.ResultsFibers determined as discriminative for
                      stimulation‐induced worsening of intelligibility were
                      mainly connected to the ipsilateral precentral gyrus as well
                      as to both cerebellar hemispheres and the ipsilateral brain
                      stem. In the thalamic area, they ran laterally to the
                      thalamus and posteromedially to the subthalamic nucleus, in
                      close proximity, mainly anterolaterally, to fibers
                      beneficial for tremor control as published by Al‐Fatly et
                      al in 2019. The overlap of the respective clinical
                      stimulation setting's VTAs with these fibers explained
                      $62.4\%$ (p < 0.001) of the variance of
                      stimulation‐induced change in intelligibility in a
                      leave‐one‐out analysis.InterpretationThis study
                      demonstrates that SID in essential tremor patients is
                      associated with both motor cortex and cerebellar
                      connectivity. Furthermore, the identified fiber‐based
                      atlas structure might contribute to future postoperative
                      programming strategies to achieve optimal tremor control
                      without speech impairment in essential tremor patients with
                      thalamic DBS. ANN NEUROL 2021;89:315–326},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33201528},
      UT           = {WOS:000592250300001},
      doi          = {10.1002/ana.25958},
      url          = {https://juser.fz-juelich.de/record/888240},
}