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000888243 1001_ $$0P:(DE-Juel1)180464$$aHasecke, Filip$$b0
000888243 245__ $$aProtofibril‐Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation
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000888243 520__ $$aAmyloid-b peptides (Ab) assemble into both rigidamyloid fibrils and metastable oligomers termed AbO orprotofibrils. In Alzheimers disease, Ab fibrils constitute thecore of senile plaques, but Ab protofibrils may represent themain toxic species. Ab protofibrils accumulate at the exterior ofsenile plaques, yet the protofibril–fibril interplay is not wellunderstood. Applying chemical kinetics and atomic forcemicroscopy to the assembly of Ab and lysozyme, protofibrilsare observed to bind to the lateral surfaces of amyloid fibrils.When utilizing Ab variants with different critical oligomerconcentrations, the interaction inhibits the autocatalytic proliferationof amyloid fibrils by secondary nucleation on thefibril surface. Thus, metastable oligomers antagonize theirreplacement by amyloid fibrils both by competing for monomersand blocking secondary nucleation sites. The protofibril—fibril interaction governs their temporal evolution andpotential to exert specific toxic activities.
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000888243 7001_ $$0P:(DE-HGF)0$$aNiyangoda, Chamani$$b1
000888243 7001_ $$0P:(DE-HGF)0$$aBorjas, Gustavo$$b2
000888243 7001_ $$0P:(DE-HGF)0$$aPan, Jianjun$$b3
000888243 7001_ $$0P:(DE-HGF)0$$aMatthews, Garrett$$b4
000888243 7001_ $$0P:(DE-HGF)0$$aMuschol, Martin$$b5$$eCorresponding author
000888243 7001_ $$0P:(DE-Juel1)166306$$aHoyer, Wolfgang$$b6$$eCorresponding author$$ufzj
000888243 773__ $$0PERI:(DE-600)2011836-3$$a10.1002/anie.202010098$$gp. anie.202010098$$n6$$p3016-3021$$tAngewandte Chemie / International edition$$v60$$x1521-3773$$y2021
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