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@ARTICLE{Gramespacher:888277,
      author       = {Gramespacher, H. and Richter, Nils and Edwin Thanarajah, S.
                      and Jacobs, H. I. L. and Dillen, K. N. H. and Nellessen, N.
                      and Reutern, B. and Dronse, J. and Kukolja, J. and Fink, G.
                      R. and Onur, O. A.},
      title        = {{A}berrant frontostriatal connectivity in {A}lzheimer's
                      disease with positive palmomental reflex},
      journal      = {European journal of neurology},
      volume       = {27},
      number       = {12},
      issn         = {1351-5101},
      address      = {Oxford},
      publisher    = {Blackwell Science91133},
      reportid     = {FZJ-2020-04803},
      pages        = {2405-2414},
      year         = {2020},
      abstract     = {Background and purposePrimitive reflexes may reoccur in
                      various neurodegenerative diseases. However, little is known
                      about their structural and functional correlates in the
                      human brain. Notably, the neural mechanisms underlying a
                      positive palmomental reflex (PMR) are poorly understood. As
                      recent studies link Alzheimer's disease (AD)‐related
                      primitive reflexes to a dysfunction of the corticostriatal
                      motor circuit (CMC), we conducted the present study to
                      investigate functional and structural correlates of a
                      positive PMR. We hypothesized an involvement of
                      frontostriatal structures and an impairment of the
                      CMC.MethodsUsing whole‐brain resting‐state functional
                      connectivity (FC), hypothesis and FC result‐based
                      probabilistic tractography, and voxel‐based morphometry
                      analyses, we compared two groups of AD patients with either
                      positive (n = 12) or negative PMR (n = 12).ResultsNo
                      significant differences in grey matter volume or structural
                      connectivity (SC) could be observed between the
                      PMR‐positive and PMR‐negative groups. In contrast, the
                      PMR‐positive group showed a decreased seed‐to‐voxel FC
                      between the bilateral supplementary motor area and parts of
                      the right‐hemispherical caudate nucleus and thalamus and a
                      decreased region of interest (ROI)‐to‐ROI FC between the
                      left putamen and the left superior frontal
                      gyrus.ConclusionData suggest that dysfunction of the CMC
                      reflected by decreased FC underlies a positive PMR in
                      patients with AD. The lack of significant grey matter or SC
                      differences might reflect that changes in FC appear before
                      changes in SC in the structures of the CMC and brain
                      atrophy.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32677282},
      UT           = {WOS:000563880000001},
      doi          = {10.1111/ene.14443},
      url          = {https://juser.fz-juelich.de/record/888277},
}