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@ARTICLE{Chien:888289,
      author       = {Chien, Wei and Gompper, Gerhard and Fedosov, Dmitry A.},
      title        = {{E}ffect of cytosol viscosity on the flow behavior of red
                      blood cell suspensions in microvessels},
      journal      = {Microcirculation},
      volume       = {28},
      number       = {2},
      issn         = {1549-8719},
      address      = {Malden, MA [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2020-04815},
      pages        = {e12668},
      year         = {2021},
      abstract     = {ObjectiveThe flow behavior of blood is strongly affected by
                      red blood cell (RBC) properties, such as the viscosity ratio
                      C between cytosol and suspending medium, which can
                      significantly be altered in several pathologies (e.g.
                      sickle‐cell disease, malaria). The main objective of this
                      study is to understand the effect of C on macroscopic blood
                      flow properties such as flow resistance in microvessels, and
                      to link it to the deformation and dynamics of single
                      RBCs.MethodsWe employ mesoscopic hydrodynamic simulations to
                      investigate flow properties of RBC suspensions with
                      different cytosol viscosities for various flow conditions in
                      cylindrical microchannels.ResultsStarting from a dispersed
                      cell configuration which approximates RBC dispersion at
                      vessel bifurcations in the microvasculature, we find that
                      the flow convergence and development of RBC‐free layer
                      (RBC‐FL) depend only weakly on C, and require a
                      convergence length in the range of 25D–50D, where D is
                      channel diameter. In vessels with
                      urn:x-wiley:10739688:media:micc12668:micc12668-math-0001,
                      the final resistance of developed flow is nearly the same
                      for C = 5 and C = 1, while for
                      urn:x-wiley:10739688:media:micc12668:micc12668-math-0002,
                      the flow resistance for C = 5 is about $10\%$ larger than
                      for C = 1. The similarities and differences in flow
                      resistance can be explained by viscosity‐dependent
                      RBC‐FL thicknesses, which are associated with the
                      viscosity‐dependent dynamics of single RBCs.ConclusionsThe
                      weak effect on the flow resistance and RBC‐FL explains why
                      RBCs can contain a high concentration of hemoglobin for
                      efficient oxygen delivery, without a pronounced increase in
                      the flow resistance. Furthermore, our results suggest that
                      significant alterations in microvascular flow in various
                      pathologies are likely not due to mere changes in cytosolic
                      viscosity.},
      cin          = {IBI-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-5-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33131140},
      UT           = {WOS:000591571900001},
      doi          = {10.1111/micc.12668},
      url          = {https://juser.fz-juelich.de/record/888289},
}