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| 001 | 888343 | ||
| 005 | 20210130010927.0 | ||
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| 100 | 1 | _ | |a de Santis, Augusta |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Not just a fluidifying effect: omega-3 phospholipids induce formation of non-lamellar structures in biomembranes |
| 260 | _ | _ | |a London |c 2020 |b Royal Soc. of Chemistry |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Polyunsaturated omega-3 fatty acid docosahexaenoic acid (DHA) is found in very high concentrations in a few peculiar tissues, suggesting that it must have a specialized role. DHA was proposed to affect the function of the cell membrane and related proteins through an indirect mechanism of action, based on the DHA-phospholipid effects on the lipid bilayer structure. In this respect, most studies have focused on its influence on lipid-rafts, somehow neglecting the analysis of effects on liquid disordered phases that constitute most of the cell membranes, by reporting in these cases only a general fluidifying effect. In this study, by combining neutron reflectivity, cryo-transmission electron microscopy, small angle neutron scattering, dynamic light scattering and electron paramagnetic resonance spectroscopy, we characterize liquid disordered bilayers formed by the naturally abundant 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and different contents of a di-DHA glycero-phosphocholine, 22:6-22:6PC, from both a molecular/microscopic and supramolecular/mesoscopic viewpoint. We show that, below a threshold concentration of about 40% molar percent, incorporation of 22:6-22:6PC in the membrane increases the lipid dynamics slightly but sufficiently to promote the membrane deformation and increase of multilamellarity. Notably, beyond this threshold, 22:6-22:6PC disfavours the formation of lamellar phases, leading to a phase separation consisting mostly of small spherical particles that coexist with a minority portion of a lipid blob with water-filled cavities. Concurrently, from a molecular viewpoint, the polyunsaturated acyl chains tend to fold and expose the termini to the aqueous medium. We propose that this peculiar tendency is a key feature of the DHA-phospholipids making them able to modulate the local morphology of biomembranes. |
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| 700 | 1 | _ | |a Vitiello, Giuseppe |0 0000-0003-3389-6942 |b 1 |
| 700 | 1 | _ | |a Appavou, Marie-Sousai |0 P:(DE-Juel1)130507 |b 2 |
| 700 | 1 | _ | |a Scoppola, Ernesto |0 0000-0002-6390-052X |b 3 |
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| 700 | 1 | _ | |a Ottaviani, Maria Francesca |0 0000-0002-4681-4718 |b 7 |
| 700 | 1 | _ | |a Paduano, Luigi |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Russo Krauss, Irene |0 0000-0001-8124-6034 |b 9 |e Corresponding author |
| 700 | 1 | _ | |a D’Errico, Gerardino |0 0000-0001-6383-8618 |b 10 |e Corresponding author |
| 773 | _ | _ | |a 10.1039/D0SM01549K |g p. 10.1039.D0SM01549K |0 PERI:(DE-600)2191476-X |n 46 |p 10425-10438 |t Soft matter |v 16 |y 2020 |x 1744-6848 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/888343/files/de%20Santis2020.pdf |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/888343/files/de%20Santis2020_PostReferee2.pdf |y Published on 2020-10-16. Available in OpenAccess from 2021-10-16. |
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