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@ARTICLE{Bosze:888469,
      author       = {Bosze, Bernadett and Ono, Yosuke and Mattes, Benjamin and
                      Sinner, Claude and Gourain, Victor and Thumberger, Thomas
                      and Tlili, Sham and Wittbrodt, Joachim and Saunders, Timothy
                      E. and Strähle, Uwe and Schug, Alexander and Scholpp,
                      Steffen},
      title        = {{P}cdh18a regulates endocytosis of {E}-cadherin during
                      axial mesoderm development in zebrafish},
      journal      = {Histochemistry and cell biology},
      volume       = {154},
      number       = {5},
      issn         = {0948-6143},
      address      = {Berlin},
      publisher    = {Springer70296},
      reportid     = {FZJ-2020-04937},
      pages        = {463-480},
      year         = {2020},
      abstract     = {The notochord defines the axial structure of all
                      vertebrates during development. Notogenesis is a result of
                      major cell reorganization in the mesoderm, the convergence
                      and the extension of the axial cells. However, it is
                      currently not fully understood how these processes act
                      together in a coordinated way during notochord formation.
                      The prechordal plate is an actively migrating cell
                      population in the central mesoderm anterior to the trailing
                      notochordal plate cells. We show that prechordal plate cells
                      express Protocadherin 18a (Pcdh18a), a member of the
                      cadherin superfamily. We find that Pcdh18a-mediated
                      recycling of E-cadherin adhesion complexes transforms
                      prechordal plate cells into a cohesive and fast migrating
                      cell group. In turn, the prechordal plate cells subsequently
                      instruct the trailing mesoderm. We simulated cell migration
                      during early mesoderm formation using a lattice-based
                      mathematical framework and predicted that the requirement
                      for an anterior, local motile cell cluster could guide the
                      intercalation and extension of the posterior, axial cells.
                      Indeed, a grafting experiment validated the prediction and
                      local Pcdh18a expression induced an ectopic prechordal
                      plate-like cell group migrating towards the animal pole. Our
                      findings indicate that the Pcdh18a is important for
                      prechordal plate formation, which influences the trailing
                      mesodermal cell sheet by orchestrating the morphogenesis of
                      the notochord.},
      cin          = {JSC / NIC},
      ddc          = {570},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / Forschergruppe Schug $(hkf6_20200501)$},
      pid          = {G:(DE-HGF)POF3-511 / $G:(DE-Juel1)hkf6_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32488346},
      UT           = {WOS:000537401300001},
      doi          = {10.1007/s00418-020-01887-5},
      url          = {https://juser.fz-juelich.de/record/888469},
}