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@ARTICLE{Wu:888505,
      author       = {Wu, Changtong and Offenhäusser, Andreas and Mayer, Dirk},
      title        = {{A} {H}ighly {S}ensitive {A}mperometric {A}ptamer
                      {B}iosensor for {A}denosine {T}riphosphate {D}etection on a
                      64 {C}hannel {G}old {M}ultielectrode {A}rray},
      journal      = {Physica status solidi / A},
      volume       = {217},
      number       = {13},
      issn         = {1862-6319},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2020-04969},
      pages        = {1900925 -},
      year         = {2020},
      abstract     = {Herein, an electrochemical aptamer biosensor based on a
                      gold multielectrode array is reported for the detection of
                      adenosine triphosphate (ATP), which is an important
                      neurotransmitter in the central nervous system. The
                      aptasensor possesses 64 individually addressable
                      microelectrodes with a diameter of 24 μm, which is
                      distributed over an area of 1 mm2. The electrodes are
                      modified with an ATP‐specific aptamer, which is labeled
                      with a ferrocene redox probe. It is demonstrated that the
                      used chip fabrication and cleaning process generate
                      microelectrode channels with similar electrochemical
                      responses and electroactive surface areas. The
                      immobilization of the aptamer on gold microelectrodes is
                      optimized and the receptor density is determined to be
                      (1.0 ± 0.44) × 1013 molecules cm−2.
                      Concentration‐dependent alternating current voltammetry
                      measurements exhibit a limit of detection of
                      0.30 × 10−9 m and a sensitivity of 2.4 nA logC.
                      Furthermore, the sensor shows a high selectivity over
                      analogous molecules and reproducible detection results in
                      artificial cerebrospinal fluid. The sensor array is used to
                      detect ATP via several channels of the same chip, showing
                      high signal redundancy. A label‐free electrochemical,
                      multichannel ATP aptasensor is demonstrated with high
                      selectivity and subnanomolar sensitivity, which may be
                      conducive to record this neurotransmitter in neuronal
                      cell‐culture systems.},
      cin          = {IBI-3},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000525922800001},
      doi          = {10.1002/pssa.201900925},
      url          = {https://juser.fz-juelich.de/record/888505},
}