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@ARTICLE{Liang:888507,
      author       = {Liang, Yuanying and Guo, Ting and Zhou, Lei and
                      Offenhäusser, Andreas and Mayer, Dirk},
      title        = {{L}abel-{F}ree {S}plit {A}ptamer {S}ensor for {F}emtomolar
                      {D}etection of {D}opamine by {M}eans of {F}lexible {O}rganic
                      {E}lectrochemical {T}ransistors},
      journal      = {Materials},
      volume       = {13},
      number       = {11},
      issn         = {1996-1944},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2020-04971},
      pages        = {2577 -},
      year         = {2020},
      abstract     = {The detection of chemical messenger molecules, such as
                      neurotransmitters in nervous systems, demands high
                      sensitivity to measure small variations, selectivity to
                      eliminate interferences from analogues, and compliant
                      devices to be minimally invasive to soft tissue. Here, an
                      organic electrochemical transistor (OECT) embedded in a
                      flexible polyimide substrate is utilized as transducer to
                      realize a highly sensitive dopamine aptasensor. A split
                      aptamer is tethered to a gold gate electrode and the analyte
                      binding can be detected optionally either via an
                      amperometric or a potentiometric transducer principle. The
                      amperometric sensor can detect dopamine with a limit of
                      detection of 1 μM, while the novel flexible OECT-based
                      biosensor exhibits an ultralow detection limit down to the
                      concentration of 0.5 fM, which is lower than all previously
                      reported electrochemical sensors for dopamine detection. The
                      low detection limit can be attributed to the intrinsic
                      amplification properties of OECTs. Furthermore, a
                      significant response to dopamine inputs among interfering
                      analogues hallmarks the selective detection capabilities of
                      this sensor. The high sensitivity and selectivity, as well
                      as the flexible properties of the OECT-based aptasensor, are
                      promising features for their integration in neuronal probes
                      for the in vitro or in vivo detection of neurochemical
                      signals.},
      cin          = {IBI-3},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32516935},
      UT           = {WOS:000551495800153},
      doi          = {10.3390/ma13112577},
      url          = {https://juser.fz-juelich.de/record/888507},
}