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@ARTICLE{Barbarino:888551,
      author       = {Barbarino, Frederik and Wäschenbach, Lucas and
                      Cavalho-Lemos, Virginia and Dillenberger, Melissa and
                      Becker, Katja and Gohlke, Holger and Cortese-Krott, Miriam
                      M.},
      title        = {{T}argeting spectrin redox switches to regulate the
                      mechanoproperties of red blood cells},
      journal      = {Biological chemistry},
      volume       = {402},
      number       = {3},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2020-05015},
      pages        = {317–331},
      year         = {2021},
      abstract     = {The mechanical properties of red blood cells (RBCs) are
                      fundamental for their physiological role as gas
                      transporters. RBC flexibility and elasticity allow them to
                      survive the hemodynamic changes in the different regions of
                      the vascular tree, to dynamically contribute to the flow
                      thereby decreasing vascular resistance, and to deform during
                      the passage through narrower vessels. RBC mechanoproperties
                      are conferred mainly by the structural characteristics of
                      their cytoskeleton, which consists predominantly of a
                      spectrin scaffold connected to the membrane via nodes of
                      actin, ankyrin and adducin. Changes in redox state and
                      treatment with thiol-targeting molecules decrease the
                      deformability of RBCs and affect the structure and stability
                      of the spectrin cytoskeleton, indicating that the spectrin
                      cytoskeleton may contain redox switches. In this perspective
                      review, we revise current knowledge about the structural and
                      functional characterization of spectrin cysteine redox
                      switches and discuss the current lines of research aiming to
                      understand the role of redox regulation on RBC mechanical
                      properties. These studies may provide novel functional
                      targets to modulate RBC function, blood viscosity and flow,
                      and tissue perfusion in disease conditions.},
      cin          = {JSC / NIC / IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
                      (SDLs) and Research Groups (POF4-511) / Forschergruppe
                      Gohlke $(hkf7_20200501)$},
      pid          = {G:(DE-HGF)POF4-5111 / $G:(DE-Juel1)hkf7_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33544503},
      UT           = {WOS:000620176300008},
      doi          = {10.1515/hsz-2020-0293},
      url          = {https://juser.fz-juelich.de/record/888551},
}