TY  - JOUR
AU  - Schmidt, Claudia C.
AU  - Timpert, David C.
AU  - Arend, Isabel
AU  - Vossel, Simone
AU  - Fink, Gereon R.
AU  - Henik, Avishai
AU  - Weiss, Peter H.
TI  - Control of response interference: caudate nucleus contributes to selective inhibition
JO  - Scientific reports
VL  - 10
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - FZJ-2020-05040
SP  - 20977
PY  - 2020
AB  - While the role of cortical regions in cognitive control processes is well accepted, the contribution of subcortical structures (e.g., the striatum), especially to the control of response interference, remains controversial. Therefore, the present study aimed to investigate the cortical and particularly subcortical neural mechanisms of response interference control (including selective inhibition). Thirteen healthy young participants underwent event-related functional magnetic resonance imaging while performing a unimanual version of the Simon task. In this task, successful performance required the resolution of stimulus–response conflicts in incongruent trials by selectively inhibiting interfering response tendencies. The behavioral results show an asymmetrical Simon effect that was more pronounced in the contralateral hemifield. Contrasting incongruent trials with congruent trials (i.e., the overall Simon effect) significantly activated clusters in the right anterior cingulate cortex, the right posterior insula, and the caudate nucleus bilaterally. Furthermore, a region of interest analysis based on previous patient studies revealed that activation in the bilateral caudate nucleus significantly co-varied with a parameter of selective inhibition derived from distributional analyses of response times. Our results corroborate the notion that the cognitive control of response interference is supported by a fronto-striatal circuitry, with a functional contribution of the caudate nucleus to the selective inhibition of interfering response tendencies.
LB  - PUB:(DE-HGF)16
C6  - pmid:33262369
UR  - <Go to ISI:>//WOS:000608976100024
DO  - DOI:10.1038/s41598-020-77744-1
UR  - https://juser.fz-juelich.de/record/888584
ER  -