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@ARTICLE{Galldiks:888589,
      author       = {Galldiks, Norbert and Jan-Michael, Werner and Lohmann,
                      Philipp and Kocher, Martin and Fink, Gereon Rudolf and
                      Langen, Karl-Josef},
      title        = {{I}maging of response to radiosurgery and immunotherapy in
                      brain metastses: {Q}uo vadis?},
      journal      = {Current treatment options in neurology},
      volume       = {23},
      number       = {3},
      issn         = {1092-8480},
      address      = {Philadelphia, Pa.},
      publisher    = {Current Science Inc.},
      reportid     = {FZJ-2020-05045},
      pages        = {7},
      year         = {2021},
      abstract     = {Purpose of ReviewThis review presents an overview of how
                      advanced imaging techniques may help to overcome
                      shortcomings of anatomical MRI for response assessment in
                      patients with brain metastases who are undergoing
                      stereotactic radiosurgery, immunotherapy, or combinations
                      thereof.Recent FindingsStudy results suggest that parameters
                      derived from amino acid PET, diffusion- and
                      perfusion-weighted MRI, MR spectroscopy, and newer MRI
                      methods are particularly helpful for the evaluation of the
                      response to radiosurgery or checkpoint inhibitor
                      immunotherapy and provide valuable information for the
                      differentiation of radiotherapy-induced changes such as
                      radiation necrosis from brain metastases. The evaluation of
                      these imaging modalities is also of great interest in the
                      light of emerging high-throughput analysis methods such as
                      radiomics, which allow the acquisition of additional data at
                      a low cost.SummaryPreliminary results are promising and
                      should be further evaluated. Shortcomings are different
                      levels of PET and MRI standardization, the number of
                      patients enrolled in studies, and the monocentric and
                      retrospective character of most studies.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000613714400001},
      doi          = {10.1007/s11940-021-00664-6},
      url          = {https://juser.fz-juelich.de/record/888589},
}