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@ARTICLE{Roush:888724,
      author       = {Roush, David and Asthagiri, Dilip and Babi, Deenesh K. and
                      Benner, Steve and Bilodeau, Camille and Carta, Giorgio and
                      Ernst, Philipp and Fedesco, Mark and Fitzgibbon, Sean and
                      Flamm, Matthew and Griesbach, Jan and Grosskopf, Tobias and
                      Hansen, Ernst B. and Hahn, Tobias and Hunt, Stephen and
                      Insaidoo, Francis and Lenhoff, Abraham and Lin, Jasper and
                      Marke, Henrik and Marques, Bruno and Papadakis, Emmanouil
                      and Schlegel, Fabrice and Staby, Arne and Stenvang, Marcel
                      and Sun, Larry and Tessier, Peter M. and Todd, Robert and
                      Lieres, Eric and Welsh, John and Willson, Richard and Wang,
                      Gang and Wucherpfennig, Thomas and Zavalov, Oleksandr},
      title        = {{T}oward in silico {CMC}: {A}n industrial collaborative
                      approach to model‐based process development},
      journal      = {Biotechnology $\&$ bioengineering},
      volume       = {117},
      number       = {12},
      issn         = {1097-0290},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2020-05159},
      pages        = {3986-4000},
      year         = {2020},
      abstract     = {The Third Modeling Workshop focusing on bioprocess modeling
                      was held in Kenilworth, NJ in May 2019. A summary of these
                      Workshop proceedings is captured in this manuscript.
                      Modeling is an active area of research within the
                      biotechnology community, and there is a critical need to
                      assess the current state and opportunities for continued
                      investment to realize the full potential of models,
                      including resource and time savings. Beyond individual
                      presentations and topics of novel interest, a substantial
                      portion of the Workshop was devoted toward group discussions
                      of current states and future directions in modeling fields.
                      All scales of modeling, from biophysical models at the
                      molecular level and up through large scale facility and
                      plant modeling, were considered in these discussions and are
                      summarized in the manuscript. Model life cycle management
                      from model development to implementation and sustainment are
                      also considered for different stages of clinical development
                      and commercial production. The manuscript provides a
                      comprehensive overview of bioprocess modeling while
                      suggesting an ideal future state with standardized
                      approaches aligned across the industry.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {583 - Innovative Synergisms (POF3-583)},
      pid          = {G:(DE-HGF)POF3-583},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32725887},
      UT           = {WOS:000563627400001},
      doi          = {10.1002/bit.27520},
      url          = {https://juser.fz-juelich.de/record/888724},
}