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000888810 1001_ $$0P:(DE-Juel1)131500$$aLoeschcke, Anita$$b0$$eCorresponding author
000888810 245__ $$aEngineering of natural product biosynthesis in Pseudomonas putida
000888810 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2020
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000888810 520__ $$aOrganisms from all kingdoms of life represent a rich source for valuable natural products with various applications. Microbial systems are useful to implement the expression of respective biosynthetic genes and establish the production and effective access to natural products, or to elucidate the biochemistry of the underlying pathways. Pseudomonas putida, a Gram-negative soil bacterium, appears to be particularly suitable for natural product biosynthesis because of an advantageous intrinsic metabolism and a remarkable tolerance toward various xenobiotics. This article presents the current state of engineering P. putida for the biosynthesis of rhamnolipids, terpenoids, polyketides, non-ribosomal peptides, and products from amino acid metabolism. Technological advances facilitating chromosomal integration and expression of biosynthetic genes, and smart metabolic engineering are key to success.
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000888810 7001_ $$0P:(DE-Juel1)128936$$aThies, Stephan$$b1
000888810 773__ $$0PERI:(DE-600)2019676-3$$a10.1016/j.copbio.2020.03.007$$gVol. 65, p. 213 - 224$$p213 - 224$$tCurrent opinion in biotechnology$$v65$$x0958-1669$$y2020
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