TY  - JOUR
AU  - Loeschcke, Anita
AU  - Thies, Stephan
TI  - Engineering of natural product biosynthesis in Pseudomonas putida
JO  - Current opinion in biotechnology
VL  - 65
SN  - 0958-1669
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2020-05224
SP  - 213 - 224
PY  - 2020
AB  - Organisms from all kingdoms of life represent a rich source for valuable natural products with various applications. Microbial systems are useful to implement the expression of respective biosynthetic genes and establish the production and effective access to natural products, or to elucidate the biochemistry of the underlying pathways. Pseudomonas putida, a Gram-negative soil bacterium, appears to be particularly suitable for natural product biosynthesis because of an advantageous intrinsic metabolism and a remarkable tolerance toward various xenobiotics. This article presents the current state of engineering P. putida for the biosynthesis of rhamnolipids, terpenoids, polyketides, non-ribosomal peptides, and products from amino acid metabolism. Technological advances facilitating chromosomal integration and expression of biosynthetic genes, and smart metabolic engineering are key to success.
LB  - PUB:(DE-HGF)16
C6  - 32498036
UR  - <Go to ISI:>//WOS:000589902000027
DO  - DOI:10.1016/j.copbio.2020.03.007
UR  - https://juser.fz-juelich.de/record/888810
ER  -